PMID: 7539432Jan 1, 1995Paper

The role of human chorionic gonadotropin beta subunit elevation in small-cell lung cancer patients

Journal of Cancer Research and Clinical Oncology
M SzturmowiczE Rowinska-Zakrzewska

Abstract

Human chorionic gonadotropin (HCG)-like immunoreactivity has been found in many non-trophoblastic tumours, but the biological behaviour of HCG-producing cells has not been clarified yet. The aim of the study was to estimate the frequency of serum HCG beta subunit (s beta HCG) elevation in patients with small-cell lung cancer (SCLC) and to assess its possible prognostic role in this type of tumour. An attempt was also made to reclassify the histology in selected cases to see whether the elevated (s beta HCG) level is connected with any special subtype of small-cell lung cancer. A total of 156 SCLC patients entered the study: 93 men, 63 women, median age 58 years. s beta HCG activity was measured by immunoenzyme assay (Abbott EIA beta HCG 15-15) before treatment. s beta HCG elevation (above 5 mIU/ml) was found in 21 of 156 patients (14%). Response to treatment after chemotherapy (complete and partial response) was obtained in only 48% of those patients in whom elevated s beta HCG was found, in comparison to the 73% response rate observed in the remaining patients. Only 5% of patients with elevated s beta HCG survived 2 years, in comparison to 21% surviving for 2 years among the remaining patients. The prognostic significance of e...Continue Reading

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Citations

Sep 18, 2007·Obstetrical & Gynecological Survey·Ezgi DemirtasTogas Tulandi
Jan 21, 2011·Journal of Medical Case Reports·Saakshi KhattriFrank Kong
Dec 10, 2008·Fetal and Pediatric Pathology·Thora S SteffensenIrwin L Browarsky
Mar 28, 2017·Endocrine-related Cancer·Georgios K DimitriadisAshley Grossman
May 17, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kuo-Ting ChangChi-Ying F Huang
Aug 15, 2003·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Subhashini YaturuSarjit Gill

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