PMID: 6967082Aug 1, 1980Paper

The role of human T cells (and T cell products) for monocyte tissue factor generation

The Journal of Immunology : Official Journal of the American Association of Immunologists
R L Edwards, F R Rickles

Abstract

Monocytes generate the procoagulant material tissue factor (TF) when mixed mononuclear cell cultures are stimulated with antigens, mitogens, or bacterial endotoxin in vitro. Optimal monocyte TF production has been shown to require the presence of lymphocytes in the culture system. We have investigated the nature of this lymphocyte requirement by stimulating monocytes grown in the presence of varying numbers of T lymphocytes. In addition, some monocytes were grown in the presence of conditioned media prepared from T lymphocyte cultures. The results of these studies have demonstrated two pathways for monocyte TF generation: a relatively T cell-independent pathway that can be stimulated by endotoxin or PPD and a highly T cell-dependent pathway that can be stimulated by PHA. In addition, the lymphocyte requirement for PHA-induced monocyte TF generation may be replaced by conditioned media from T cell cultures.

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

International Archives of Allergy and Applied Immunology
M SchatzI M Suszko
Acta Pathologica Et Microbiologica Scandinavica. Section C, Immunology
G Unsgaard
Biulleten' eksperimental'noĭ biologii i meditsiny
L V GankovskaiaE P Pogorel'skaia
© 2021 Meta ULC. All rights reserved