Abstract
The role of hyperthermia during regional alkylating agent chemotherapy is controversial. The aim of this study was to determine the exact contribution of hyperthermia to tumor response during isolated limb infusion with l-phenylalanine mustard. Rats bearing rodent fibrosarcoma on the hindlimb underwent isolated limb infusion with saline, saline plus heat, l-phenylalanine mustard, l-phenylalanine mustard under conditions of normothermia, or l-phenylalanine mustard plus hyperthermia. Heat was administered locally using an in-line hot water circulation loop. Treatment with l-phenylalanine mustard at a concentration of 15 or 50 micrograms/mL was ineffective at producing tumor growth delay (P = 0.24 and 0.41, respectively). Furthermore, thermal enhancement of l-phenylalanine mustard activity was not seen at 15 micrograms/mL. However, administration of high-dose l-phenylalanine mustard, 50 micrograms/mL, with increasing amounts of heat yielded increasing tumor growth delay, increased regressions, and decreased proliferative index. Although l-phenylalanine mustard infusion under normothermia yielded a tumor growth delay of 7.1 days, combination l-phenylalanine mustard + hyperthermia treatment produced tumor growth delay of 27.0 days (...Continue Reading
References
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J M KlaaseH R Franklin
Dec 9, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J van der ZeeH H Kampinga
Oct 6, 2001·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·K Ohnishi, T Ohnishi
Jul 6, 2002·Critical Reviews in Oncology/hematology·Bert HildebrandtHanno Riess
Oct 1, 1958·Annals of Surgery·O CREECHJ N WINBLAD
Apr 1, 1961·Cleveland Clinic Quarterly·G CRILE
May 1, 1960·Annals of Surgery·B WOODHALLH T DUKES
Sep 1, 1962·Annals of Surgery·W W SHINGLETON
Citations
Nov 10, 2006·Annals of Surgical Oncology·Mohamed A F HegazyOmar Farouk
Feb 3, 2009·Annals of Surgical Oncology·N McMahonDouglas S Tyler
Jun 6, 2008·Annals of Surgical Oncology·Georgia M BeasleyDouglas S Tyler
Oct 16, 2009·Annals of Surgical Oncology·Andrew P BarbourB Mark Smithers
Feb 26, 2010·Annals of Surgical Oncology·Hiroaki ToshimitsuDouglas S Tyler
Mar 19, 2011·Annals of Surgical Oncology·Georgia M Beasley, Douglas S Tyler
Nov 26, 2013·Best Practice & Research. Clinical Anaesthesiology·Radha ArunkumarPascal Owusu-Agyemang
Apr 9, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·James C PadussisPaul J Mosca
Apr 9, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Hunter R Moyer, Keith A Delman
Aug 29, 2014·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Benjamin L VigliantiGregory M Palmer
Sep 6, 2012·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Jens JakobPeter Hohenberger
Oct 8, 2011·Expert Opinion on Drug Metabolism & Toxicology·Dale HanJonathan S Zager
Sep 2, 2014·Expert Opinion on Drug Metabolism & Toxicology·Omar M RashidJonathan S Zager
Nov 30, 2010·Surgical Oncology Clinics of North America·Ryan S TurleyDouglas S Tyler
Oct 16, 2010·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S R GrobmyerS N Hochwald
Aug 30, 2008·Surgical Oncology Clinics of North America·Peter C A Kam, John F Thompson
Jul 2, 2011·Journal of Surgical Oncology·Marcello PaceLuigi Millanta
Jul 8, 2014·Surgery Today·Minhyung KimIl Young Park
Jun 3, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S BonvalotA Le Cesne
Jan 7, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sae Hee KoDouglas S Tyler
May 17, 2008·Cancer Research·Christina K AugustineDouglas S Tyler
May 8, 2007·Molecular Cancer Therapeutics·Yasunori YoshimotoDouglas S Tyler
Mar 21, 2006·Molecular Cancer Therapeutics·Tomio UenoDouglas S Tyler