The role of hyperthermic intraperitoneal intraoperative chemotherapy in ovarian cancer

Current Treatment Options in Oncology
W J van DrielG S Sonke

Abstract

Epithelial ovarian cancer (EOC) is the fourth most common gynecologic cancer in Europe and is the leading cause of death among women with gynecologic malignancies. This is due to the fact that the majority of the patients are diagnosed with advanced stage disease. In these stages, extensive intraperitoneal metastases are often present, making therapy more difficult. The current standard treatment involves primary or interval cytoreductive surgery and chemotherapy. However, many patients develop intraperitoneal (IP) recurrences despite complete surgery and chemotherapy. Therefore, alternative ways to deliver chemotherapy have been examined. Administration of the chemotherapy directly into the peritoneal cavity allows high doses of the cytotoxic agent at the site of the cancer, while minimizing the occurrence of systemic side effects. Theoretically, IP administration is most beneficial when only microscopic disease is present since penetration of the drug is limited to a few millimeters. IP chemotherapy can be administered during surgery under hyperthermic conditions (HIPEC) or during regular chemotherapy courses through a catheter placed into the abdominal cavity. IP administration results in an improved survival, although cathe...Continue Reading

References

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Citations

Oct 11, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Y R HuoD L Morris
Sep 10, 2016·Journal of Pharmaceutical and Biomedical Analysis·Charlotte CarlierWim Ceelen
Jul 7, 2017·International Review of Psychiatry·Camilla GesiLiliana Dell'Osso
Jan 18, 2018·The New England Journal of Medicine·Willemien J van DrielGabe S Sonke
May 30, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Qiwen WuXiao Li
Sep 30, 2020·Technology in Cancer Research & Treatment·Ya-Zheng DangJie Li
Sep 13, 2017·The Cochrane Database of Systematic Reviews·Jae Hung JungPhilipp Dahm
Feb 23, 2017·Molecular Cancer Therapeutics·Karem A CourtMadeline Torres-Lugo

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