The role of hypoxia in the hyperglycaemic effect of xylazine in sheep

Zentralblatt für Veterinärmedizin. Reihe A
D Raptopoulos

Abstract

Xylazine (0.2 mg/kg, i.v.) was administered to sheep breathing room air (group X) or oxygen (group XO). Xylazine induced a rise in serum glucose concentration which, following a sharp increase in the first 30 minutes, remained at similar high levels (about 165% of the pre-injection value) for another 2.5 hours. Arterial PCO2 was slightly increased and reached a significant level at 5 and 15 minutes following xylazine injection in group X. In group XO, at all sampling times after the injection, PaCO2 showed a similar pattern of increase, although the effect was not significant. Arterial PO2 was decreased significantly for at least 60 minutes. Hypoxia by itself can induce hyperglycaemia, but its prevention by administering oxygen did not alter the hyperglycaemic effect of xylazine. It was concluded that the hypoxia following administration of xylazine was not severe enough to produce a rise in catecholamine concentrations eliciting hyperglycaemia.

References

Oct 1, 1979·Endocrinology·I D Goldfine, A I Arieff
Jun 1, 1975·The Journal of Physiology·C T Jones, R O Robinson
Jun 1, 1986·Journal of Veterinary Pharmacology and Therapeutics·A NolanA Waterman
Jun 1, 1985·Endocrinology·S M Abdel el Motal, G W Sharp
Jan 1, 1987·Zentralblatt für Veterinärmedizin. Reihe A·P BrikasA Ayiannidis
Dec 1, 1988·Journal of Veterinary Pharmacology and Therapeutics·S A Greene, J C Thurmon
Jan 1, 1985·Journal of Biomechanics·R Vincentelli, M Grigorov
Mar 5, 1981·European Journal of Pharmacology·L HedlerK Starke
Jun 9, 1984·The Veterinary Record·D Raptopoulos, B M Weaver
Dec 1, 1982·Journal of Veterinary Pharmacology and Therapeutics·J C ThurmonT F Lock
Jan 2, 1982·British Medical Journal·R H Greenwood

❮ Previous
Next ❯

Citations

Dec 1, 1995·Journal of Veterinary Pharmacology and Therapeutics·D RaptopoulosT J Parkinson
Feb 16, 2006·Veterinary Anaesthesia and Analgesia·Sabine B R Kästner
Jun 21, 2001·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·S B KästnerR Bettschart-Wolfensberger
Nov 22, 2005·Critical Reviews in Biotechnology·R E Madrid, C J Felice

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.