The role of IgG1 and IgG2 in trimellitic anhydride-induced allergic response in the guinea pig lung

Toxicology and Applied Pharmacology
D G FraserJean F Regal

Abstract

Trimellitic anhydride (TMA) is a small molecular weight chemical used in the paint and plastics industry that can cause asthma-like symptoms in humans. Guinea pigs sensitized intradermally with TMA will respond to antigen challenge with asthma-like symptoms, including an immediate bronchoconstriction and a delayed cellular infiltration into the lung, particularly eosinophil infiltration. Sensitized guinea pigs produce TMA-specific IgG1, which is thought to be important in asthmatic reactions in this animal model; however, they also produce TMA-specific IgG2 antibody. The purpose of the present study was to determine the role of IgG1 and IgG2 in the TMA-induced immediate bronchoconstriction and delayed cellular infiltration in the guinea pig. Guinea pigs were passively sensitized by intratracheal instillation of TMA-specific IgG2, an antibody preparation enriched with TMA-specific IgG1, or a combination of the two. The allergic response was induced by intratracheal instillation of TMA conjugated to guinea pig serum albumin (TMA-GPSA). A significantly greater bronchoconstrictor response was observed in animals sensitized with a combination of the IgG2 and IgG1 preparation compared to those sensitized with IgG2 or the IgG1 prepara...Continue Reading

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Citations

Mar 15, 2002·International Archives of Allergy and Immunology·Christen P Larsen, Jean F Regal
Jul 26, 2011·Journal of Allergy·Victor J JohnsonBerran Yucesoy
Mar 18, 2000·Proceedings of the Society for Experimental Biology and Medicine·J F RegalN A Greenberg
Jun 6, 2020·Clinical Science·Mikael AdnerSven-Erik Dahlén
Jul 22, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Patricia Ramos-RamírezMikael Adner
Dec 14, 2017·Human & Experimental Toxicology·A ElkamaA E Karakaya
Oct 30, 2008·Journal of Immunotoxicology·Jean F Regal

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