The role of βIII-tubulin in non-small cell lung cancer patients treated by taxane-based chemotherapy.

International Journal of Clinical Oncology
Kyoichi KairaNobuyuki Yamamoto

Abstract

The aim of this study is to evaluate whether class III β-tubulin (TUBB3) expression could predict progression-free survival or overall survival in relapsed non-small cell lung cancer (NSCLC) patients treated with taxene-based chemotherapy. Immunohistochemistal staining was used to examine the expression of TUBB3 in resected lung tumor specimens obtained from 56 patients treated with platinum-based chemotherapy against recurrent tumors after curative resections. Excision repair cross-complementation group 1, breast cancer susceptibility gene 1, vascular endothelial growth factor, Ki-67, CD34, and p53 were also correlated with clinical features and outcome after treatment. Of the 56 patients enrolled in the study, 29 were treated by carboplatin plus paclitaxel as first-line treatment, and 24 patients received docetaxel monotherapy as second- or third-line treatment. A positive TUBB3 expression is closely associated with a poor response to taxane-based chemotherapy. TUBB3 expression was an independent prognostic factor for predicting poor progression-free survival after docetaxel administration. However, TUBB3 expression could not predict outcome after carboplatin plus paclitaxel treatment. The other biomarkers tested were not ind...Continue Reading

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Citations

Aug 15, 2014·Cancer Chemotherapy and Pharmacology·Qiang ZhangYong Lin
Aug 13, 2015·International Journal of Clinical Oncology·Kyoichi KairaMasanobu Yamada
Oct 17, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wanjun YuJipeng Li
Oct 13, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fermín PersonFrank Jacobsen
Sep 22, 2020·Expert Opinion on Drug Delivery·Archana UpadhyaAmbikanandan Misra
Jan 18, 2017·British Journal of Cancer·Ahmed Sk Al-KhafajiTriantafillos Liloglou
Apr 18, 2018·Journal of Cellular Physiology·Ren WangXiao-Yan Jin

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