The role of IL-12 and TNF-alpha in AIDP and AMAN

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
H DengJ Zhu

Abstract

Acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and acute motor axonal neuropathy (AMAN) have been described as two major subtypes of Guillain-Barré syndrome (GBS); however, the possible difference of their immune-inflammatory pathogenesis remains unclear. In this study, by using FACS and enzyme-linked immunosorbent assays analyses, the role of Th1 cytokines tumour necrosis factor-alpha (TNF-alpha), interleukin-12 (IL-12) and their receptors on peripheral blood mononuclear cells (PBMCs) and in serum concentrations were investigated in AIDP and AMAN. The results showed enhanced IL-12, IL-12R1 in AIDP and TNF-alpha in AMAN during the acute phase, as well as increased TNF-alpha and TNFR1 during the plateau phase of AIDP. Intravenous high dose immunoglobulin decreased IL-12R1 expression on cells in AIDP, but increased TNF-alpha and TNFR2 in AMAN. Our data suggest that IL-12 promotes disease development in AIDP and in contrast to previously inflammatory assumptions, TNF-alpha may play double roles in GBS. The anti-inflammatory role of TNF-alpha realized through TNFR2 in AMAN is possibly a therapeutic mechanism in the IVIg treatment of AMAN.

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Citations

Nov 26, 2010·Journal of Neurology·Ming-Ou Lu, Jie Zhu
Jun 25, 2013·Cytokine & Growth Factor Reviews·Hong-Liang ZhangJie Zhu
Apr 18, 2014·Journal of Clinical Immunology·Nevena TzekovaPatrick Küry
Apr 2, 2016·Mediators of Inflammation·Xueli FanTao Jin
Oct 10, 2015·Mediators of Inflammation·Ying WangHong-Liang Zhang
Nov 8, 2016·Expert Opinion on Therapeutic Targets·Ying WangHong-Liang Zhang
Feb 9, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lin-Jie ZhangLi Yang
Oct 9, 2020·Journal of Molecular Neuroscience : MN·Amin SafaSoudeh Ghafouri-Fard

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