The role of IL-18 in type 1 diabetic nephropathy: The problem and future treatment

Cytokine
Nehal M Elsherbiny, Mohammed M H Al-Gayyar

Abstract

Diabetic vascular complication is a leading cause of diabetic nephropathy, a progressive increase in urinary albumin excretion coupled with elevated blood pressure leading to declined glomerular filtration and eventually end stage renal failure. There is growing evidence that activated inflammation is contributing factor to the pathogenesis of diabetic nephropathy. Meanwhile, IL-18, a member of the IL-1 family of inflammatory cytokines, is involved in the development and progression of diabetic nephropathy. However, the benefits derived from the current therapeutics for diabetic nephropathy strategies still provide imperfect protection against renal progression. This imperfection points to the need for newer therapeutic agents that have potential to affect primary mechanisms contributing to the pathogenesis of diabetic nephropathy. Therefore, the recognition of IL-18 as significant pathogenic mediators in diabetic nephropathy leaves open the possibility of new potential therapeutic targets.

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Citations

Jan 24, 2018·Journal of Diabetes Research·Olivia LenoirPierre-Louis Tharaux
Nov 13, 2018·Journal of Cellular Physiology·Habib YaribeygiAmirhossein Sahebkar
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Apr 4, 2021·International Journal of Molecular Sciences·Naila QayyumSangdun Choi
Jul 6, 2021·Disease Markers·Youdi WangJialin Gao

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