The role of IL-20 in chronic kidney disease and diabetic nephropathy: Pathogenic and therapeutic implications

Journal of Leukocyte Biology
Ming-Shi Chang, Yu-Hsiang Hsu

Abstract

Chronic kidney disease and its complications are a major public health problem worldwide. Diabetic nephropathy has become the main contributing cause of terminal renal failure. There are now evidences that different inflammatory molecules, including proinflammatory cytokines, play a critical role in the development of microvascular diabetic complications, including nephropathy. IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory disorders likes psoriasis, atherosclerosis, and renal failure. This review discusses the role of IL-20 as a pathogenic factor in renal injury, focusing on chronic kidney disease and diabetic nephropathy, and describes potential treatment strategies based on modulation of IL-20's function.

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Citations

Oct 22, 2019·Endocrine Reviews·Yuliya LytvynDavid Z I Cherney
Aug 11, 2020·Oxidative Medicine and Cellular Longevity·Jing GuoWei Jing Liu
Feb 8, 2020·International Journal of Molecular Sciences·Tian-Yu Lin, Yu-Hsiang Hsu

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