The role of immunohistochemical markers in the diagnosis of follicular-patterned lesions of the thyroid.

Endocrine Pathology
Sylvia L Asa

Abstract

Thyroid nodules are extremely common in the general population. The differential diagnosis includes numerous entities, non-neoplastic and neoplastic, benign and malignant. However, the diagnosis of follicular-patterned lesions remains an area fraught with controversy and diagnostic criteria are highly variable. It is, therefore, a field in need of objective, scientific markers that better characterize these lesions than has been possible by classical morphology. A number of candidates have been proposed. No single marker can identify all malignant follicular-patterned lesions, however, various combinations have been proposed. They include HBME-1, high molecular weight cytokeratins and ret, galectin-3 and TPO, galectin-3, fibronectin-1, CITED-1, HBME-1, and CK19. Advances in our understanding of the molecular basis of thyroid cancer will allow the identification of new markers and more accurate characterization of specific subtypes of neoplasia and malignancy. As new markers are characterized and validated, directed by molecular profiling of thyroid lesions with characteristic morphology, behavior, and outcome, they will become available as routine immunohistochemical markers that will provide a more accurate, scientific, and cl...Continue Reading

Citations

Jun 11, 2009·Bulletin of Experimental Biology and Medicine·T L Poloz, V A Shkurupiy
Oct 26, 2006·Journal of Molecular Histology·Mariza A MatsumotoDaniel A Ribeiro
May 14, 2011·Plant & Cell Physiology·Daisuke Saisho, Kazuyoshi Takeda
Feb 26, 2016·Archives of Pathology & Laboratory Medicine·Parnian Ahmadi MoghaddamAshraf Khan
Oct 21, 2015·Diagnostic Cytopathology·Anthony SimmsMomin T Siddiqui
May 31, 2012·Diagnostic Cytopathology·Mary D KinsellaMomin T Siddiqui
Apr 21, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ivan PaunovicSvetlana Savin
Mar 25, 2015·Journal of the Egyptian National Cancer Institute·Fatma El-Zahraa Salah El-Deen Yassin
Dec 31, 2014·Archives of Pathology & Laboratory Medicine·Haiyan Liu, Fan Lin
May 27, 2010·Virchows Archiv : an International Journal of Pathology·Sofia AsioliGianni Bussolati
Oct 13, 2012·Advances in Anatomic Pathology·Ozgur Mete, Sylvia L Asa
Aug 3, 2017·Journal of Pathology and Translational Medicine·Ju Yeon PyoSoonWon Hong
Nov 5, 2013·Applied Immunohistochemistry & Molecular Morphology : AIMM·Magdy Hassan KotbShahenda Sabry Salem
Jun 6, 2020·Diagnostic Cytopathology·Neeta KumarSanjay Gupta
Jan 1, 2008·Biomarker Insights·Rosaria M RuggeriMaria Trovato
Nov 28, 2009·Arquivos brasileiros de endocrinologia e metabologia·Inês Vieira de Castro
Nov 28, 2009·Arquivos brasileiros de endocrinologia e metabologia·Rita C FerreiraPatrícia S de Matos
Oct 20, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Enrico SaggioratoFabio Orlandi
Mar 6, 2008·Archives of Pathology & Laboratory Medicine·Sandra Fischer, Sylvia L Asa

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