The Role of Immunotherapy in Multiple Myeloma

Pharmaceuticals
Mehmet Kocoglu, Ashraf Badros

Abstract

Multiple myeloma is the second most common hematologic malignancy. The treatment of this disease has changed considerably over the last two decades with the introduction to the clinical practice of novel agents such as proteasome inhibitors and immunomodulatory drugs. Basic research efforts towards better understanding of normal and missing immune surveillence in myeloma have led to development of new strategies and therapies that require the engagement of the immune system. Many of these treatments are under clinical development and have already started providing encouraging results. We, for the second time in the last two decades, are about to witness another shift of the paradigm in the management of this ailment. This review will summarize the major approaches in myeloma immunotherapies.

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Methods Mentioned

BETA
Transgenic

Clinical Trials Mentioned

NCT01827137
NCT00834665
NCT00090493
NCT00948961
NCT01380145
NCT00988312
NCT00186316
NCT01426828
NCT00162500
NCT01232712

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