The role of infection in the pathogenesis of autoimmune disease

Seminars in Immunology
N R Rose

Abstract

Autoimmune disease has long been considered a shadow following infectious diseases. Epidemiological evidence shows that rheumatic fever follows streptococcal infection and Trypanosoma cruzi infection is the instigator of Chagas' disease. There is, however, very little information of the mechanism by which such a train of events is initiated. Autoimmunity, in a form of autoantibodies, is common after many infections and may well result from the mimicking of host proteins by antigens of the infectious agent. There are, however, few if any examples in humans where molecular mimicry gives rise to autoimmune disease. The progression from benign autoimmunity to pathogenic autoimmune disease depends upon the balance of cytokines produced during the inflammatory process accompanying infection. In many autoimmune diseases, the cytokine profile favors the proinflammatory cytokines, IFN-gamma and IL-1, which support the production of disease. A searching study of cytokine profiles during infection may offer a promising approach to avoiding the harmful consequences of post-infection autoimmune responses.

Citations

Sep 1, 2009·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M S GableC A Glaser
Jan 4, 2008·Immunology and Cell Biology·Joanna Groom, Fabienne Mackay
Jun 6, 2009·The New England Journal of Medicine·Manuel G CosioAlvar Agusti
Dec 10, 1999·The Journal of Experimental Medicine·F MackayJ L Browning
Oct 9, 2009·Viral Immunology·Maite Duhalde-VegaLilia A Retegui
Oct 16, 2002·Annals of the Rheumatic Diseases·M HuhtinenM Leirisalo-Repo
Nov 13, 2002·Annual Review of Immunology·Fabienne MackayJeffrey Browning
Sep 30, 1999·Environmental Health Perspectives·N R RoseC L Burek
Dec 12, 2012·International Journal of Molecular Sciences·Eirini NeofytouNikolaos M Siafakas
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·J DesbaratsM K Newell
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·B ChackerianJ T Schiller
Apr 4, 2012·Expert Opinion on Drug Discovery·Alberto K De la Herrán-Arita, René Drucker-Colín
Jun 26, 2012·Expert Opinion on Drug Delivery·Kattya Gyselle De Holanda E SilvaEryvaldo Socrates Tabosa Do Egito
Sep 11, 2008·Autoimmunity·Adita Mascaro-BlancoMadeleine W Cunningham
Nov 10, 2013·Biological Psychiatry·Michael E BenrosPreben B Mortensen
Dec 13, 2006·Clinical & Developmental Immunology·Ljudmila Stojanovich
Mar 5, 2009·International Immunopharmacology·José L AparicioLilia A Retegui
Nov 25, 2003·Helicobacter·Fabio PresottoCorrado Betterle
Sep 18, 2009·Annals of the New York Academy of Sciences·Amy D ProalTrevor G Marshall
Nov 24, 2006·Clinical Endocrinology·Victoria SundbladEduardo H Charreau
Oct 13, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Carlo Selmi
Jul 25, 2012·Annals of the New York Academy of Sciences·Michael E BenrosWilliam W Eaton
Aug 26, 2011·Annals of Neurology·Fang HanEmmanuel Mignot
Dec 15, 2004·Microbes and Infection·Chandrashekhar Pasare, Ruslan Medzhitov
Dec 9, 2014·Journal of Theoretical Biology·Robert Root-Bernstein, DeLisa Fairweather
May 5, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·A Parikh-PatelM E Gershwin
Dec 6, 2003·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Florence GoulhenDenis Mayrand
May 7, 2004·Journal of Clinical Gastroenterology·Carlo SelmiEmmet B Keefe
Apr 21, 2018·Nature Reviews. Rheumatology·Frederick W MillerKanneboyina Nagaraju
Aug 7, 2003·Expert Review of Vaccines·Frank DeStefanoRobert T Chen
Nov 15, 2002·International Journal of Hematology·Richard K BurtAlberto M Marmont
May 1, 2007·Expert Review of Clinical Immunology·Alexander N KhitrovSergey V Suchkov
Mar 1, 2008·Expert Review of Clinical Immunology·Carlo SelmiM Eric Gershwin
Dec 12, 2012·The Tohoku Journal of Experimental Medicine·Milomir MilanovicEleonora Gvozdenovic
Jul 15, 2017·Journal of Pharmacology & Pharmacotherapeutics·Sahoo AshokkumarVikram Kate

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