The role of infections and leukocytes in male infertility.

Andrologia
Ralf HenkelDavid Fisher

Abstract

Declining birth rates are one of the problems facing society today. Male counterparts are responsible for about half of the infertility cases, and genitourinary tract infections may play a contributing role in approximately 15% of male infertility cases. Leukocytospermia is an established indicator of infection in the male urogenital tract, although other microorganisms such as bacteria and virus may also be contributors to the etiology of male infertility. The pathophysiology of these infectious agents may be initiated by a local inflammatory reaction resulting in an increase in reactive oxygen species (ROS). This results in testicular injury, thereby affecting sperm morphology, sperm motility, sperm viability and elevation of the seminal leukocyte as a result of the genital tract infection. The infectious and inflammatory changes can result in male infertility. It is proposed that high concentrations of seminal leukocyte and infectious agents may affect sperm function resulting in clumping of motile spermatozoa, decreasing acrosomal functionality and also causing alterations in sperm morphology. However, the literature has poorly clarified the role of infection in male infertility, provoking further debate and research on thi...Continue Reading

References

Aug 1, 1979·The British Journal of Venereal Diseases·C I GomezR P Williams
Jan 1, 1992·Journal of Clinical Periodontology·G DahlénO Fejerskov
Sep 1, 1991·Archives of Andrology·H VillegasS Karchmer
Jan 1, 1990·The Prostate·G WildingC E Freter
Oct 1, 1990·The Journal of Urology·C E CloseR E Berger
Jul 1, 1989·Biology of Reproduction·R J AitkenS Fishel
Sep 1, 1987·Fertility and Sterility·M I el-DemiryG D Chisholm
Mar 1, 1973·Journal of Reproduction and Fertility·V Barták
Jan 1, 1968·Acta Obstetricia Et Gynecologica Scandinavica·B Fjällbrant, O Obrant
Oct 1, 1983·Transplantation·J R HeadR E Billingham
May 1, 1983·The Journal of Infectious Diseases·H BrunnerH G Schiefer
Feb 1, 1980·International Journal of Andrology·F ComhaireL Vermeulen
Jun 1, 1995·Fertility and Sterility·H Wolff
Mar 1, 1994·American Journal of Reproductive Immunology : AJRI·F ComhaireF Schoonjans
Jan 1, 1993·Cancer Investigation·J P Richie
Jan 1, 1993·World Journal of Urology·N Bar-Chama, H Fisch
Jun 1, 1993·International Journal of Andrology·A W KungC Wang
Feb 1, 1993·International Journal of Andrology·K Purvis, E Christiansen
May 1, 1993·The American Journal of Clinical Nutrition·H Esterbauer
Nov 1, 1995·Archives of Andrology·J Fedder, S Ellerman-Eriksen
Jun 1, 1997·Urology·R O RobertsS J Jacobsen
Jul 1, 1997·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·N KjaergaardH Madsen
Nov 20, 1997·The Journal of Urology·R CasellaT C Gasser
Mar 24, 1998·Urology·J C Nickel
Jun 18, 1998·Andrologia·F M KöhnW B Schill

❮ Previous
Next ❯

Citations

Nov 3, 2020·Andrologia·Edmund KoAshok Agarwal
Jun 26, 2021·The World Journal of Men's Health·Rakesh SharmaGiovanni M Colpi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

World Journal of Urology
N Bar-Chama, H Fisch
The Journal of International Medical Research
F S Al-Joudi, J A K Jamil
Gynécologie, obstétrique & fertilité
D EissO Hélénon
Oxidative Medicine and Cellular Longevity
Giulia CollodelCinzia Signorini
© 2021 Meta ULC. All rights reserved