The role of inflammation in post-thrombotic syndrome after pregnancy-related deep vein thrombosis: A population-based, cross-sectional study

Thrombosis Research
H S WikP M Sandset

Abstract

Previous studies suggest that inflammation may play a role in the pathophysiology of post-thrombotic syndrome (PTS). The aims of the present study were to evaluate markers of inflammation as possible predictors for PTS after pregnancy-related deep vein thrombosis (DVT). We included 182 women with a pregnancy-related DVT during 1990-2003 and 314 controls. All women answered a questionnaire and donated a blood sample in 2006. PTS was diagnosed when a self-reported Villalta score was above 4. The following predictors of PTS were included: high sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, IL-8, IL-10, monocyte chemotactic protein (MCP)-1, transforming growth factor (TGF)-β1, platelet derived growth factor (PDGF)-BB, and the two adhesion molecules intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1. High values were defined as above median value among controls. We found that 41% of cases were diagnosed with PTS 3-16years after index pregnancy. In univariate analyses, high values of hsCRP, IL-6, and IL-10 were significantly associated with PTS with ORs 2.3 (95% CI; 1.2-4.2, p=0.008), 1.9 (1.0-3.5, p=0.04), and 10.8 (1.3-89.8, p=0.01), respectively. Only hsCRP, which has previously been...Continue Reading

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Citations

Aug 10, 2016·Thrombosis Research·Marc Rodger, Henri H Versteeg
Aug 24, 2019·Journal of Clinical Laboratory Analysis·Xun WangJin Zhang
Aug 13, 2021·European Journal of Obstetrics & Gynecology and Reproductive Biology: X·Susanne HesselmanAnna Sandström
Dec 9, 2019·ACS Biomaterials Science & Engineering·Jiwon KimDong-Eog Kim
Sep 25, 2021·Seminars in Reproductive Medicine·Benjamin BrennerMaria Tretyakova

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