Abstract
Previous studies suggest that inflammation may play a role in the pathophysiology of post-thrombotic syndrome (PTS). The aims of the present study were to evaluate markers of inflammation as possible predictors for PTS after pregnancy-related deep vein thrombosis (DVT). We included 182 women with a pregnancy-related DVT during 1990-2003 and 314 controls. All women answered a questionnaire and donated a blood sample in 2006. PTS was diagnosed when a self-reported Villalta score was above 4. The following predictors of PTS were included: high sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, IL-8, IL-10, monocyte chemotactic protein (MCP)-1, transforming growth factor (TGF)-β1, platelet derived growth factor (PDGF)-BB, and the two adhesion molecules intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1. High values were defined as above median value among controls. We found that 41% of cases were diagnosed with PTS 3-16years after index pregnancy. In univariate analyses, high values of hsCRP, IL-6, and IL-10 were significantly associated with PTS with ORs 2.3 (95% CI; 1.2-4.2, p=0.008), 1.9 (1.0-3.5, p=0.04), and 10.8 (1.3-89.8, p=0.01), respectively. Only hsCRP, which has previously been...Continue Reading
References
Aug 8, 2007·Journal of Vascular Surgery·Lornie J Phillips, Rajabrata Sarkar
Nov 13, 2007·American Journal of Obstetrics and Gynecology·Anne Flem JacobsenPer Morten Sandset
Mar 28, 2008·Journal of Thrombosis and Haemostasis : JTH·A F JacobsenP M Sandset
Nov 20, 2008·Annals of Internal Medicine·Susan R KahnJeffrey S Ginsberg
Jan 30, 2009·Journal of Thrombosis and Haemostasis : JTH·E M Roumen-KlappeM Den Heijer
Jan 30, 2009·Journal of Thrombosis and Haemostasis : JTH·S R KahnUNKNOWN Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on T
Mar 12, 2009·Thrombosis and Haemostasis·Hadia ShbakloSusan R Kahn
Sep 11, 2009·Blood·Susan R Kahn
Dec 17, 2011·Lancet·Tone EndenUNKNOWN CaVenT Study Group
May 31, 2012·Journal of Thrombosis and Haemostasis : JTH·A C BoumanA J Ten Cate-Hoek
Jun 1, 2012·Journal of Thrombosis and Haemostasis : JTH·J-P GalanaudS R Kahn
Aug 1, 2012·Journal of Thrombosis and Haemostasis : JTH·R S ChitsikeS R Kahn
Jan 3, 2013·Journal of Thrombosis and Haemostasis : JTH·J P GalanaudS R Kahn
Apr 16, 2013·Journal of Thrombosis and Haemostasis : JTH·A Perrier, H Bounameaux
Dec 10, 2013·Lancet·Susan R KahnUNKNOWN SOX trial investigators
May 21, 2014·Phlebology·Sk van der Velden, Ham Neumann
Jul 1, 2014·Thrombosis Research·A C BoumanA J ten Cate-Hoek
Jan 13, 2015·Thrombosis Research·Luis Fernando BittarJoyce M Annichino-Bizzacchi
Mar 3, 2015·Phlebology·F S CatarinellaC H A Wittens
May 6, 2015·Thrombosis Research·Stefano de Franciscis, Raffaele Serra
Sep 26, 2015·International Wound Journal·Stefano de FranciscisRaffaele Serra
Citations
Aug 10, 2016·Thrombosis Research·Marc Rodger, Henri H Versteeg
Aug 24, 2019·Journal of Clinical Laboratory Analysis·Xun WangJin Zhang
Dec 7, 2017·Oncotarget·Jianhui WuShiqi Peng
Jun 7, 2018·Frontiers in Medicine·Knut A MosevollHåkon Reikvam
Aug 13, 2021·European Journal of Obstetrics & Gynecology and Reproductive Biology: X·Susanne HesselmanAnna Sandström
Dec 9, 2019·ACS Biomaterials Science & Engineering·Jiwon KimDong-Eog Kim
Sep 25, 2021·Seminars in Reproductive Medicine·Benjamin BrennerMaria Tretyakova