The role of inhalational anesthetic drugs in patients with hepatic dysfunction: a review article

Anesthesiology and Pain Medicine
Hassan SoleimanpourSeyed Moayed Alavian

Abstract

Anesthetic drugs including halogenated anesthetics have been common for many years. Consequent hepatic injury has been reported in the literature. The mechanism of injury is immunoallergic. The first generation drug was halothane; it had the most toxicity when compared to other drugs. The issue becomes more important when the patient has an underlying hepatic dysfunction. In this paper, reputable internet databases from 1957-2014 were analyzed and 43 original articles, 3 case reports, and 3 books were studied. A search was performed based on the following keywords: inhalational anesthesia, hepatic dysfunction, halogenated anesthetics, general anesthesia in patients with hepatic diseases, and side effects of halogenated anesthetics from reliable databases. Reputable websites like PubMed and Cochrane were used for the searches. In patients with hepatic dysfunction in addition to hepatic system and dramatic hemostatic dysfunction, dysfunction of cardiovascular, renal, respiratory, gastrointestinal, and central nervous systems may occur. On the other hand, exposure to inhalational halogenated anesthetics may have a negative impact (similar to hepatitis) on all aforementioned systems in addition to direct effects on liver function a...Continue Reading

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Citations

Aug 19, 2017·International Journal of Toxicology·Qiang ShiWilliam F Salminen
Jun 4, 2016·Hepatitis Monthly·Hassan SoleimanpourSeyed Moayed Alavian
Jun 13, 2017·Anesthesia Progress·Gina ChenJames W Tom
Nov 16, 2016·Anesthesiology and Pain Medicine·Maryam SoleimanpourSeyed Moayed Alavian
Apr 17, 2019·Clinical Liver Disease·Jerome C Edelson, Don C Rockey
Mar 18, 2017·Current Opinion in Anaesthesiology·Malgorzata H StarczewskaPeter Shirley

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