Abstract
The left dorsal premotor cortex (PMd) plays an important role in movement selection and is abnormally activated in imaging studies in patients with right-sided focal hand dystonia (FHD). The aims of this study were to assess the role of left PMd in patients with FHD and in the genesis of surround inhibition, which is deficient in FHD. Single- and paired-pulse transcranial magnetic stimulation (TMS) was applied during different phases of an index finger movement using the abductor pollicis brevis muscle (APB), a surrounding, nonsynergistic muscle, as target muscle. To look at the effect of PMd on the primary motor cortex (M1), a subthreshold conditioning pulse was applied to PMd 6 milliseconds before stimulation over M1. There was surround inhibition during movement initiation in controls, but not in FHD patients. In contrast, FHD patients, but not controls, showed premotor-motor inhibition (PMI) at rest. During movement, PMI was absent in both groups. We conclude that PMI does not appear to play a key role in the formation of surround inhibition in normal subjects, because it was not enhanced during movement initiation. However, in FHD, inhibition from PMd on M1 was abnormally increased at rest and declined during movement init...Continue Reading
References
Jul 1, 1988·Neurology·L G Cohen, M Hallett
Mar 1, 1971·Neuropsychologia·R C Oldfield
Oct 1, 1993·Movement Disorders : Official Journal of the Movement Disorder Society·G PaulettiM Manfredi
Nov 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·M C RiddingT Kujirai
May 1, 1996·Neurology·K IkomaM Hallett
Apr 1, 1997·Brain : a Journal of Neurology·A O Ceballos-BaumannD J Brooks
Oct 27, 1997·Neurology·R ChenM Hallett
Jun 10, 1998·Brain : a Journal of Neurology·N D SchluterK R Mills
Jul 29, 1998·Brain : a Journal of Neurology·A BerardelliC D Marsden
Jul 17, 1999·Neurology·V IbáñezM Hallett
Feb 13, 2001·Neuropsychologia·N D SchluterR E Passingham
Nov 15, 2001·NeuroImage·C CivardiJ C Rothwell
Aug 16, 2002·The Journal of Physiology·Zafiris J DaskalakisRobert Chen
Nov 5, 2003·NeuroImage·M F S RushworthJ T Devlin
Jan 28, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·V Di LazzaroJ C Rothwell
Mar 10, 2004·NeuroImage·Alicja LernerMark Hallett
Apr 1, 2004·Cerebral Cortex·Cathy M Stinear, Winston D Byblow
May 18, 2004·Experimental Brain Research·Young H Sohn, Mark Hallett
Jul 14, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Giacomo KochJohn C Rothwell
May 18, 2007·Journal of Neurophysiology·Winston D ByblowUlf Ziemann
Jan 5, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Giacomo KochJohn C Rothwell
Oct 10, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sandra BeckMark Hallett
Citations
Mar 23, 2011·Experimental Brain Research·Sandra Beck, Mark Hallett
Jun 3, 2011·Journal of Neurology·Cécile GalléaEmmanuel Roze
Aug 15, 2013·The Cerebellum·G GrimaldiU Ziemann
Sep 10, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Antonella ConteAlfredo Berardelli
Nov 30, 2012·Experimental Brain Research·Lidwien C VeugenBart P van de Warrenburg
Jan 9, 2013·The International Journal of Neuroscience·Anna SadnickaMark J Edwards
Dec 6, 2011·Expert Opinion on Therapeutic Targets·Valerie B ThompsonEllen J Hess
Nov 13, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·S Beck, M Hallett
Nov 25, 2011·Human Brain Mapping·Cathérine C S DelnoozIvan Toni
Aug 14, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Cathérine C S DelnoozBart P C van de Warrenburg
Apr 9, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Sarah Pirio RichardsonMark Hallett
Aug 1, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Anne WeissbachAlexander Münchau
Jun 25, 2015·NeuroImage. Clinical·C GalleaS Lehericy
Dec 4, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Sarah Pirio Richardson
Apr 15, 2014·Brain Imaging and Behavior·Victoria GonzalezPhilippe Coubes
Nov 13, 2012·Experimental Neurology·Daniele BelvisiAlfredo Berardelli
Jan 29, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Anna SadnickaMark Edwards
Aug 24, 2016·IEEE Transactions on Haptics·Seyed Farokh AtashzarRajni V Patel
Apr 30, 2015·PloS One·Sarah Pirio RichardsonRobert Chen
Feb 21, 2018·Brain Topography·Sara ParmigianiLuigi Cattaneo
Sep 22, 2018·Brain and Behavior·Maria BerndtBernhard Haslinger
Feb 1, 2012·The European Journal of Neuroscience·Elise HoudayerMark Hallett
Jun 28, 2011·Brain : a Journal of Neurology·Diane RugeJohn C Rothwell
Jul 11, 2012·The European Journal of Neuroscience·Brach PostonMark Hallett
Jun 5, 2015·Journal of Neurophysiology·Nivethida ThirugnanasambandamMark Hallett
Oct 9, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Antonella ConteAlfredo Berardelli
Sep 30, 2020·The European Journal of Neuroscience·Alana B McCambridge, Lynley V Bradnam
Dec 28, 2019·Brain Stimulation·Nivethida ThirugnanasambandamMark Hallett