The role of inhibitory molecules in fracture healing

Injury
Rozalia DimitriouP V Giannoudis

Abstract

The balance between all the signalling molecules involved in bone formation with their inhibitors and most importantly between BMPs and their antagonists is critical determinant of osteogenesis, and therefore of skeletal development, fracture repair, and bone remodelling. The main identified inhibitory molecules of the osteogenic lineage, either from studies during embryonic development or from in vitro and in vivo studies are presented in the herein study. Potential treatments using these molecules either alone or in combination with BMPs to control the bone growth and overgrowth are already under investigation aiming in treatments that mimic as much as possible the natural process of bone generation in various situations including fracture healing, osteoporosis, and osteoarthritis and other metabolic disorders, in order to more closely resemble the original tissue.

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Citations

Jan 29, 2008·Injury·Peter V GiannoudisDavid Marsh
Jan 29, 2008·Injury·Peter V GiannoudisDavid Marsh
Feb 13, 2013·Injury·R DimitriouP V Giannoudis
Jun 24, 2011·International Orthopaedics·Suzanne N Lissenberg-ThunnissenInger B Schipper
Feb 16, 2013·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Burak Yagmur OzturkDeniz Erdogan
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Jun 9, 2015·Bone·Gonzalo Sánchez-DuffhuesPeter Ten Dijke
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Jul 12, 2008·Injury·Stuart J E MatthewsPeter V Giannoudis
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Howa BegamAbhijit Chanda
Jul 10, 2009·Clinical Orthopaedics and Related Research·Bruno DohinReggie Hamdy
Apr 21, 2017·International Orthopaedics·Gopal Shankar KrishnakumarGiuseppe Filardo
Apr 13, 2019·Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology·Paul Andrzejowski, Peter V Giannoudis
Aug 8, 2021·Cells·Filip Simunovic, Günter Finkenzeller

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