The role of initial 18 F-FDG PET/CT in the management of patients with suspected extramedullary plasmocytoma

Cancer Imaging : the Official Publication of the International Cancer Imaging Society
Linqi ZhangWei Fan

Abstract

Extramedullary plasmacytoma (EMP) is a plasma cell malignancy that originates in soft tissues without evidence of systemic spread, and its management differs from other plasma cell neoplasms. The purpose of the present study was to evaluate the role of initial 18F-FDG PET/CT in the management of patients with clinical suspected EMP. 18F-FDG PET/CT scans performed in 21 patients (M/F = 12/9, mean age 51.1 ± 15.3 years) with clear suspicion of EMP from 2006 to 2015 were analysed retrospectively. The detection of new lesions and the change in treatment were evaluated. PET/CT detected new lesions in 38.1% (8/21) of patients with 17 lesions, and lymph nodes were the most common site, accounting for 70.6% (12/17) of all lesions, followed by bone (n = 2), and less frequently, breast (n = 1), lung (n = 1), and stomach (n = 1). These findings resulted in treatment changes in 7 patients with EMP. Among these, 4 patients had major treatment changes and 3 patients had minor changes. Of the 21 patients, progression to MM was observed in 8 patients (8/21, 38.1%). In univariate analysis, tumour size > 4 cm and partial response (PR) after treatment were significant prognostic factors for Progression-free survival (PFS). Our data indicated that...Continue Reading

References

Nov 25, 2003·Cancer Biotherapy & Radiopharmaceuticals·Holger SchirrmeisterMartin Bommer
Nov 24, 2005·Hematology·Donna M Weber
Dec 14, 2005·International Journal of Radiation Oncology, Biology, Physics·Laetitia Tournier-RangeardDidier Peiffert
Jun 4, 2008·Haematologica·Pierre-Yves SalaunFrançoise Bodéré-Kraeber
Nov 29, 2008·International Journal of Radiation Oncology, Biology, Physics·Paul J KimMichael P Mac Manus
Jul 14, 2009·American Journal of Clinical Oncology·Roi DaganWilliam M Mendenhall
Feb 22, 2011·Annals of Hematology·Sonja KrauseDirk Neuhof
Jun 2, 2012·TheScientificWorldJournal·Sevil KilciksizAyfer Haydaroglu
Oct 25, 2013·Clinical Nuclear Medicine·Yazan Z AlabedJerome Laufer
Dec 18, 2013·International Forum of Allergy & Rhinology·Christine D'AguilloJean Anderson Eloy
Jul 19, 2014·World Journal of Orthopedics·Thorsten Derlin, Peter Bannas
May 29, 2015·Clinical Nuclear Medicine·Pierpaolo AlongiJamshed Bomanji
Dec 20, 2015·British Journal of Haematology·Paola FinsingerMaria T Petrucci
Mar 22, 2016·Critical Reviews in Oncology/hematology·Giuseppe RubiniFrancesco Dammacco
Aug 22, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Domenico AlbanoFrancesco Bertagna

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Citations

Jan 15, 2019·Journal of Magnetic Resonance Imaging : JMRI·Weiguo ZhangMartin R Prince
Nov 26, 2019·Nuclear Medicine Communications·Ben ShacharUr Metser
Aug 16, 2019·BMC Cancer·Sridevi Hanaganahalli BasavaiahKrishna Prasad
Jul 18, 2021·Head & Neck·Monica H XingMark L Urken

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