The role of innate immunity in the induction of autoimmunity

Autoimmunity Reviews
David S Pisetsky

Abstract

The autoimmune diseases are a diverse group of conditions characterized by abnormal B and T cell reactivity in association with autoantibody production. Among these diseases, systemic lupus erythematosus (SLE) is notable for the expression of antibodies to DNA, with these antibodies representing diagnostic markers. While mammalian DNA is immunologically inert, DNA from bacteria can potently stimulate the innate immune system, activating both toll-like receptors (TLRs) as well as non-TLR internal receptors. Since the sera of normal humans contain antibodies specific for bacterial DNA, this molecule appears to be immunogenic during infection. In pre-autoimmune mice, immunization with bacterial DNA can induce anti-DNA autoantibody production, suggesting a role in initiating this response. The immune properties of DNA are mutable, however, since mammalian DNA can acquire immunological activity when bound to certain proteins or anti-DNA antibodies to form immune complexes. In SLE, these immune complexes can drive the production of interferon by plasmacytoid dendritic cells, thereby intensifying autoimmunity. Together, these observations suggest that DNA can induce innate as well as adaptive immune responses and promote the pathogene...Continue Reading

References

Mar 1, 1995·The Journal of Clinical Investigation·G S GilkesonD S Pisetsky
Nov 5, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·D S Pisetsky, C F Reich
Aug 17, 2000·Springer Seminars in Immunopathology·D S Pisetsky
Feb 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Emily C BaechlerTimothy W Behrens
Jun 23, 2004·Trends in Immunology·Hermann Wagner
Mar 2, 2005·The Journal of Experimental Medicine·Sergey YurasovMichel C Nussenzweig
Jun 28, 2005·Trends in Immunology·Ingrid E DumitriuPatrizia Rovere-Querini
Nov 22, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Kimberly J HamiltonDavid S Pisetsky
Nov 23, 2005·The Journal of Experimental Medicine·Yasutaka OkabeShigekazu Nagata
Jan 18, 2006·Immunity·Daniel B Stetson, Ruslan Medzhitov
Feb 1, 2006·Arthritis and Rheumatism·Lars RönnblomGunnar V Alm
Jul 22, 2006·EMBO Reports·Helena Erlandsson Harris, Angela Raucci
Sep 19, 2006·Trends in Immunology·Ken J Ishii, Shizuo Akira
May 5, 2007·Nature Medicine·Holger KanzlerRobert L Coffman

❮ Previous
Next ❯

Citations

Jan 21, 2009·Clinical Reviews in Allergy & Immunology·Srini V Kaveri
Dec 21, 2010·Clinical Reviews in Allergy & Immunology·Luca CantariniMauro Galeazzi
Aug 17, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jaewoo LeeBruce A Sullenger
Jun 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Hideyuki YanaiTadatsugu Taniguchi
Jun 23, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Emmy K BellWilliam J Cook
May 7, 2013·Orphanet Journal of Rare Diseases·Peter JanssensZahir Amoura
Jun 12, 2010·Arthritis Research & Therapy·R Hal Scofield
Oct 17, 2012·Arthritis Research & Therapy·Aditya K PandaBidyut K Das
Mar 9, 2010·International Journal of Clinical Rheumatology·Lisa Francis, Andras Perl
Nov 17, 2010·Indian Journal of Dermatology, Venereology and Leprology·Mohit Mittal, Siba P Raychaudhuri
Mar 29, 2013·Autoimmunity Reviews·Paola CavalcanteRozen Le Panse
Apr 10, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S EspositoD Rigante
Aug 1, 2015·International Journal of Molecular Sciences·Donato Rigante, Susanna Esposito
Dec 19, 2014·Autoimmunity·Vuslat YilmazGüher Saruhan-Direskeneli
Dec 12, 2012·Autoimmunity Reviews·C TarellaA Cignetti
Nov 12, 2009·Autoimmunity Reviews·Ian Logan, Christopher L Bowlus
Sep 1, 2009·Autoimmunity Reviews·Siba P RaychaudhuriM Eric Gershwin
Jan 24, 2009·Autoimmunity Reviews·Hanspeter Waldner
Feb 13, 2009·Autoimmunity Reviews·Monica MartaAnna Lobell
May 7, 2015·Mediators of Inflammation·Yunzhi Xu, Guangjie Chen
Mar 26, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·R Brian StevensLucile E Wrenshall
Aug 26, 2009·Scandinavian Journal of Immunology·K-Y Su, D S Pisetsky
Sep 18, 2009·Annals of the New York Academy of Sciences·Natasa Toplak, Tadej Avcin
Sep 18, 2009·Annals of the New York Academy of Sciences·Marco TucciFranco Silvestris
Sep 18, 2009·Annals of the New York Academy of Sciences·Monica Marta
Mar 21, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·N KaracaA Berdeli
Mar 17, 2010·Journal of Veterinary Emergency and Critical Care·Edward B BreitschwerdtMichael R Lappin
Apr 28, 2009·Autoimmunity Reviews·Amy D ProalTrevor Marshall
Apr 28, 2009·Autoimmunity Reviews·Elad Goldberg, Ilan Krause
Aug 19, 2015·Molecular and Cellular Endocrinology·Ravichandran PanchanathanDivaker Choubey
Jun 3, 2015·Nature Reviews. Rheumatology·Ole P Rekvig
Sep 21, 2013·Autoimmunity Reviews·Donato RiganteSusanna Esposito
Oct 14, 2014·Autoimmunity Reviews·Luca CantariniDonato Rigante

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.