PMID: 6160036Sep 1, 1980Paper

The role of inorganic phosphate in the release of Ca2+ from rat-liver mitochondria

European Journal of Biochemistry
I RoosE Carafoli

Abstract

The effect of inorganic phosphate on Ca2+ retention has been investigated using phosphate-depleted liver mitchondria. Phosphate induces the release of Ca2+ through an efflux route insensitive to ruthenium red. This effect is not due to functional or structural damage, since mitochondria maintain their membrane potential during phosphate-induced Ca2+ efflux. Direct enzymatic measurement of mitochondria pyridine nucleotides has established that changes in their redox state (i.e. increased oxidation) do not play a role in the phosphate-effect. The phosphate-induced Ca2+ efflux requires transport of phosphate out of mitochondria. However, the fluxes of Ca2+ and phosphate do not coincide: the release of phosphate preceeds that of Ca2+.

References

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Citations

Aug 1, 1983·Journal of Bioenergetics and Biomembranes·A MasiniU Muscatello
Jul 1, 1982·Biulleten' eksperimental'noĭ biologii i meditsiny·M Kh GaĭnutdinovIa Kh Turakulov
Jan 1, 1984·The International Journal of Biochemistry·F RigoniR Deana
Jan 1, 1988·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M L MunozE C Weinbach
May 1, 1997·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·C BravoR Moreno-Sánchez
Oct 1, 1982·European Journal of Biochemistry·F Zoccarato, D Nicholls
Oct 1, 1984·European Journal of Biochemistry·J Nedergaard
Sep 1, 1988·Kidney International·A ConfortyC Chaimovitz
May 19, 2011·Mitochondrion·Pinadda Varanyuwatana, Andrew P Halestrap
Jun 22, 2016·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Zofia TyneckaZofia Goś-Szcześniak
Oct 15, 1982·Archives of Biochemistry and Biophysics·E J Harris, J J Heffron
Jul 1, 1982·Archives of Biochemistry and Biophysics·K Lê-Quôc, D Lê-Quôc
Jun 15, 1981·FEBS Letters·F Zoccarato, D G Nicholls
Jan 1, 1990·Cell Biochemistry and Function·T Nakagawa, P J Butterworth
Aug 16, 2005·The Journal of Biological Chemistry·Valentina BattagliaAntonio Toninello
Jul 17, 1995·Biochimica Et Biophysica Acta·M Zoratti, I Szabò
Sep 1, 1982·Biochimica Et Biophysica Acta·D Nicholls, K Akerman
Aug 1, 1985·Archives of Biochemistry and Biophysics·G Fiskum, R S Cockrell

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