The Role of Insular Cortex in Response to Group Therapy in Vaginismus Patients: Magnetic Resonance Spectroscopy Study

Psychiatry Investigation
Mehmet Fatih Erbay, Esra Porgalı Zayman

Abstract

Disgust has been propounded as a potential etiological factor in certain sexual dysfunctions such as vaginismus. Studies reports that insular cortex is activated as a response to disgust. The present study aimed to investigate the predictive role of metabolites in insular cortex in response to group therapy among vaginismus patients. Study sample consisted of 51 vaginismus patients attended an ambulatory group therapy, of whom 26 benefited from 8-week group therapy and 25 were unresponsive to group therapy. All of the patients underwent H magnetic resonance spectroscopy (H-MRS), and insular cortex N-acetyl aspartate (NAA), Creatinine (Cr), Glutamine (Gln), Glutathione (GSH), Choline (Cho), Myo-inositol (mIns), Glutamate (Glu) and Lactate (Lac) concentrations were compared between the groups. Comparing insular cortex metabolite concentrations between the groups, Cho was statistically significantly higher (p=0.005) but mIns was significantly lower (p=0.001) in the unresponsive to group therapy group. MR spectroscopy findings of the present study indicated significant metabolic changes such as increased Cho/Cr ratio and decreased mIns/Cr ratio in the insular cortex of vaginismus patients who were unresponsive to group therapy. Our...Continue Reading

References

Jun 7, 2005·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Dieter VaitlRudolf Stark
Jun 15, 2005·Biological Psychiatry·Nick J CouplandPeter S Allen
May 16, 2006·Behaviour Research and Therapy·Bunmi O OlatunjiDavid F Tolin
Jul 11, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ivan TkácRolf Gruetter
Nov 13, 2009·Nutrition Reviews·Steven H Zeisel, Kerry-Ann da Costa
Apr 7, 2010·The Journal of Sexual Medicine·Charmaine BorgWillibrord Weijmar Schultz
Aug 31, 2010·Journal of Anxiety Disorders·Iris M EngelhardPeter J de Jong
Jan 5, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Valerie CurtisRobert Aunger
Mar 1, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·David A CamfieldMichael Berk
Aug 8, 2012·Journal of Anxiety Disorders·Kristin N Bianchi, Michele M Carter
Oct 24, 2012·The Journal of Sexual Medicine·Mark van OverveldMoniek M ter Kuile
Dec 5, 2012·Psychological Review·Joshua M TyburPeter DeScioli
Apr 1, 2008·Acta Neuropsychiatrica·Clarissa TrzesniakJosé Alexandre S Crippa
Aug 11, 2018·Current Psychiatry Reports·Kelly A KnowlesBunmi O Olatunji
Sep 15, 2018·Frontiers in Behavioral Neuroscience·Megan OatenTrevor I Case
May 10, 2019·Frontiers in Behavioral Neuroscience·Kathrin ViolGuenter Karl Schiepek

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Statistical Program for Social Sciences

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