PMID: 39551Jun 15, 1979

The role of insulin in the regulation of stearic acid desaturase activity in liver and adipose tissue from obese--hyperglycaemic (ob/ob) and lean mice

The Biochemical Journal
M Enser

Abstract

The relationship between the hyperinsulinaemia of obese--hyperglycaemic (ob/ob) mice and their high activity of stearic acid delta 9-desaturase compared with lean mice has been investigated. The concentrations of plasma insulin in obese mice were decreased by 71, 88 and 96% after treatment either with alloxan or food restriction to maintain the same weight as lean mice, or treatment of the weight restricted mice with alloxan followed by feeding ad libitum. The concentration of plasma insulin produced by the latter treatment was the same as in normal lean mice. After treatment the hepatic desaturase activities were 24, 68 and 19% less respectively on a cell basis than in livers from untreated obese mice, and the total epididymal fat-pad activities were lower by 16, 62 and 57%. These results suggest that hyperinsulinaemia is not essential for the increased hepatic desaturase, controlling the hepatic desaturase activity, but even this may be subject to overriding regulation by the concentration of esterified linoleic acid in the liver lipids, which was negatively correlated (r = 0.91, P less than 0.001) with desaturase activity.

Citations

Sep 25, 2012·Progress in Lipid Research·Leanne Hodson, Barbara A Fielding
Dec 11, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·François PaillardPhilippe Legrand
Aug 17, 2000·Bioscience, Biotechnology, and Biochemistry·M ChungY Choi
Feb 19, 1998·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·M KoubaP Peiniau
Dec 1, 1992·The Proceedings of the Nutrition Society·M Ashwell
Feb 1, 1983·Metabolism: Clinical and Experimental·L A Menahan
May 16, 2008·Journal of Cell Communication and Signaling·Daniel MauvoisinCatherine Mounier
Nov 19, 2010·The American Journal of Clinical Nutrition·Jian GongAna Baylin
Jan 1, 1981·Progress in Biophysics and Molecular Biology·P J Quinn

Related Concepts

Fat Pad
Alloxan
Blood Glucose
Ingestion
Epididymis
Saturated Fat
Novolin
Liver
Mouse, Hyperglycemic
Stearoyl-CoA Desaturase

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