The role of insulin-regulated aminopeptidase in MHC class I antigen presentation.

Frontiers in Immunology
Loredana Saveanu, Peter van Endert

Abstract

Production of MHC-I ligands from antigenic proteins generally requires multiple proteolytic events. While the proteolytic steps required for antigen processing in the endogenous pathway are clearly established, persisting gaps of knowledge regarding putative cross-presentation compartments have made it difficult to map the precise proteolytic events required for generation of cross-presented antigens. It is only in the past decade that the importance of aminoterminal trimming as the final step in the endogenous presentation pathway has been recognized and that the corresponding enzymes have been described. This review focuses on the aminoterminal trimming of exogenous cross-presented peptides, with particular emphasis on the identification of insulin responsive aminopeptidase (IRAP) as the principal trimming aminopeptidase in endosomes and phagosomes.

Citations

Aug 12, 2014·Nucleic Acids Research·Queralt Seguín-EstévezWalter Reith
Apr 3, 2013·Molecular Immunology·Efstratios Stratikos, Lawrence J Stern
Apr 15, 2016·Assay and Drug Development Technologies·Karin EngenMats Larhed
Nov 6, 2012·Molecular Immunology·Loredana SaveanuPeter van Endert
Jul 5, 2013·PloS One·Christina YipMatthew D Linden
Feb 18, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Alexandros NikolaouJo A Van Ginderachter
Aug 25, 2012·Molecular & Cellular Proteomics : MCP·Noel García-MedelJosé A López de Castro
Oct 26, 2018·Inflammatory Bowel Diseases·Kimi DrobinJonas Halfvarson
Feb 19, 2017·The Journal of Experimental Medicine·Muhammad-Al-Mustafa IsmailAngel Cedazo-Mínguez
Mar 21, 2017·Nature Immunology·Joel BabdorLoredana Saveanu
Aug 15, 2020·Frontiers in Immunology·Fabiana PaladiniRosa Sorrentino
Jun 4, 2020·Nature Communications·Irini EvnouchidouLoredana Saveanu
Oct 20, 2020·Frontiers in Pharmacology·Dimitris GeorgiadisAntonia Papasava
Dec 10, 2020·Médecine sciences : M/S·Irini EvnouchidouLoredana Saveanu
Oct 24, 2020·Biomolecules·Aigul Sharip, Jeannette Kunz
Nov 17, 2020·Frontiers in Molecular Biosciences·Delphyne DescampsLoredana Saveanu
Nov 8, 2020·Cancers·María Jesús Ramírez-ExpósitoJose Manuel Martínez-Martos
Jul 6, 2020·Trends in Cell Biology·Gwyn W GouldNia J Bryant

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Methods Mentioned

BETA
transfection
GTPases
co-immunoprecipitation
two-hybrid
flow cytometry
fluorescence microscopy

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