The Role of Integrative and Conjugative Elements in Antibiotic Resistance Evolution.

Trends in Microbiology
João Botelho, Hinrich Schulenburg

Abstract

Mobile genetic elements (MGEs), such as plasmids and integrative and conjugative elements (ICEs), are main drivers for the spread of antibiotic resistance (AR). Coevolution between bacteria and plasmids shapes the transfer and stability of plasmids across bacteria. Although ICEs outnumber conjugative plasmids, the dynamics of ICE-bacterium coevolution, ICE transfer rates, and fitness costs are as yet largely unexplored. Conjugative plasmids and ICEs are both transferred by type IV secretion systems, but ICEs are typically immune to segregational loss, suggesting that the evolution of ICE-bacterium associations varies from that of plasmid-bacterium associations. Considering the high abundance of ICEs among bacteria, ICE-bacterium dynamics represent a promising challenge for future research that will enhance our understanding of AR spread in human pathogens.

Citations

Sep 30, 2020·FEMS Microbiology Reviews·Michiel KleerebezemOscar van Mastrigt
Sep 29, 2020·Frontiers in Microbiology·Sara Hernando-AmadoJosé L Martínez
Dec 23, 2020·The ISME Journal·Rachel M Wheatley, R Craig MacLean
Feb 11, 2021·BMC Biology·Itamar SelaEugene V Koonin
Mar 7, 2021·Trends in Microbiology·Nancy ObengHinrich Schulenburg
Apr 6, 2021·Frontiers in Cellular and Infection Microbiology·Ting YuDongsheng Zhou
Jul 3, 2021·Frontiers in Cellular and Infection Microbiology·Xinhua LuoDongsheng Zhou
Oct 23, 2021·The Science of the Total Environment·Maria Luíza Soares SuhadolnikAndréa Maria Amaral Nascimento
Nov 30, 2021·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·James P J HallDavid A Baltrus
Nov 30, 2021·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Elizabeth PurseyStineke van Houte

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