PMID: 9540090Apr 16, 1998Paper

The role of integrin beta 1 in human dental pulp cell adhesion on laminin and fibronectin

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Q ZhuL S Spångberg

Abstract

This study is to identify the expression of integrin beta 1 in human dental pulp cells and the role of integrin beta 1 in pulp cell adhesion on extracellular matrix protein laminin and fibronectin. Immunoblot detection of integrin beta 1 in human pulp cells was with the use of monoclonal anti-beta 1 antibody. Dental pulp cell adhesion assay on extracellular matrix protein laminin and fibronectin and blocking cell adhesion was performed with monoclonal anti-beta 1 antibody. Integrin beta 1 was identified in human dental pulp cells. Pulp cells adhered and spread on both laminin and fibronectin. Monoclonal anti-beta 1 antibody inhibited human dental pulp cells adhesion on laminin but not on fibronectin. Integrin beta 1 was expressed on human dental pulp cells and mediated cell adhesion on laminin. Human dental pulp cells also adhered on fibronectin but the adhesion was not regulated by beta 1 integrin.

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Citations

May 12, 2006·Periodontology 2000·Tanida SrisuwanKeren M Abberton
Dec 13, 2005·Cell and Tissue Research·M-J StaquetJ-C Farges

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