PMID: 6165276Jan 1, 1980Paper

The role of interferon in immediate hypersensitivity and autoimmune diseases

Annals of the New York Academy of Sciences
J J HooksA L Notkins

Abstract

We have presented evidence showing that interferon can enhance the IgE-mediated release of histamine. We have also shown that immune interferon is present in the circulation of patients with certain autoimmune diseases. Furthermore, there is a positive correlation between active systemic lupus erythematosus and interferon levels. Systemic lupus erythematosus is characterized by immune hyperactivity. The continuous presence of type II, immune interferon in the circulation of these patients may, on one hand, contribute to the immunological aberrations, while on the other hand, protect against viral infections. At the present time we are looking for interferon in the circulation of patients with other autoimmune disorders.

References

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Citations

Jan 1, 1989·Immunologic Research·E GrunebaumY Shoenfeld
Mar 1, 1989·The Journal of Experimental Medicine·A M YeeY K Yip
Dec 8, 1998·Journal of the American Academy of Dermatology·C L MehtaD J Cripps
Oct 16, 2013·Drug Discovery Today·Kenzie D MacIsaacChristopher Roberts
Sep 7, 2014·Cytokine & Growth Factor Reviews·Hiroki Kato, Takashi Fujita
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·W J Richtsmeier
Apr 1, 1982·Arthritis and Rheumatism·S R Ytterberg, T J Schnitzer
Apr 15, 1989·International Journal of Cancer. Journal International Du Cancer·M LakhdarR Kastally

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