The role of interfragmentary strain on the rate of bone healing-a new interpretation and mathematical model

Journal of Biomechanics
D ComiskeyJ O'Byrne

Abstract

It is postulated that there is a causal relationship between mechanical stimulus and the rate of bone healing post fracture. However, despite numerous experimental studies in the literature, no quantifiable relationship has been proposed. It is hypothesized in the present study that the temporal rate of bone fracture healing, measured in terms of callus stiffening per week, can be described mathematically based on the relative motions between bone fragments at the initial stage of the healing process. To test this, a comparative reanalysis of experimental data found in the literature was conducted. These individual data sets described a relationship between an initial intermittently applied peak interfragmentary strain and the change in interfragmentary motion or the increase in callus stiffness over time. The data were converted into a relative increase in stiffness, which normalised the results and reduced inter-study variability. The rates of healing for the various initial strains were compared, and based on this a mathematical phenomenological model was derived. Error analyses were then performed, which showed a high level of congruence between the in-vivo and simulated rates of healing. The results of the comparative anal...Continue Reading

References

Jan 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·E J ChealS M Perren
Jul 1, 1997·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·L ClaesH J Wilke
Jan 12, 2001·International Orthopaedics·G Mora, F Forriol
Jun 12, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Petra KleinGeorg N Duda
Jun 9, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R HenteS M Perren
Jul 18, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Lutz ClaesBettina Willie
Jan 1, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Allen E GoodshipClinton T Rubin

❮ Previous
Next ❯

Citations

Jan 12, 2013·Biomechanics and Modeling in Mechanobiology·D ComiskeyJ O'Byrne
Oct 22, 2014·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Esther Reina-RomoJaime Domínguez
Jul 24, 2013·World Journal of Orthopedics·Fatih KüçükdurmazMurat Bezer
Nov 2, 2017·Annals of the New York Academy of Sciences·Natacha RosaAntonio Torres Marques
Feb 19, 2016·The Journal of Bone and Joint Surgery. American Volume·Jacob ElkinsWilliam Lack
Mar 15, 2019·International Journal for Numerical Methods in Biomedical Engineering·Ganesharajah GanadhiepanLihai Zhang
Mar 20, 2019·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Jianzhao WangYingze Zhang
Mar 20, 2019·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Natacha RosaAntonio Torres Marques
Dec 15, 2020·The Journal of Bone and Joint Surgery. American Volume·Vaida GlattChristopher Iobst

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Computer Methods in Biomechanics and Biomedical Engineering
D ComiskeyJ O'Byrne
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
E G LoboaD R Carter
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
E J ChealS M Perren
© 2021 Meta ULC. All rights reserved