PMID: 1201010Jul 1, 1975Paper

The role of intermediates in mitochondrial fatty acid oxidation

The Biochemical Journal
K K Stanley, P K Tubbs

Abstract

1. Rat liver mitochondria oxidizing [16-14C]palmitoylcarnitine accumulate saturated long-chain thiester intermediates which may be detected by radio-g.1.c.2. Time-courses of intermediate accumulation display no product-precursor relationships and the end product, measured as [14C]citrate, is produced without a detectable initial lag. 3. A short pulse of [16-14C]palmitoylcarnitine followed by unlabelled palmitoylcarnitine showed that the observed intermediates(at least in the greater part)were not the direct precursors of [14C]citrate. 4. The quantity of saturated intermediates depended on the total accumulated flux of acyl units through the pathway provided that some mitochondrial CoA and unused substrate remained. 5. In the presence of rotenone and carnitine, 2-unsaturated, 3-unsaturated and 3-hydroxy intermediates were formed as well as saturated intermediates...

Citations

Mar 15, 1994·European Journal of Biochemistry·S EatonK Bartlett
Feb 1, 1978·European Journal of Biochemistry·M Lopes-CardozoS G van den Bergh
Jan 1, 1988·Annals of the New York Academy of Sciences·R C Murphy, D O Stene
Aug 19, 2014·Frontiers in Physiology·Miguel A AonSonia C Cortassa
Oct 1, 1978·Archives of Biochemistry and Biophysics·V W van HinsberghH T van Moerkerk
May 15, 1988·Analytical Biochemistry·P M LatipääJ K Hiltunen
Mar 1, 1982·Muscle & Nerve·J B ShumateR M Choksi
May 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S KrähenbühlJ Reichen
Aug 1, 1984·Circulation Research·P B CorrB E Sobel
Feb 13, 2010·Journal of Inherited Metabolic Disease·Niels Gregersen, Rikke K J Olsen
Aug 1, 1980·European Journal of Biochemistry·Y Olowe, H Schulz
Mar 1, 1986·Neuroscience and Behavioral Physiology·S N KhayutinL P Dmitrieva
Jan 1, 1986·Neuroscience and Behavioral Physiology·L M Chuppina, I G Vlasova
Jul 26, 1996·The Journal of Biological Chemistry·K W Yao, H Schulz
Jan 13, 1995·The Journal of Biological Chemistry·M A NadaC R Roe
Jan 20, 2004·European Journal of Biochemistry·Kim Bartlett, Simon Eaton
Jan 30, 2002·Progress in Lipid Research·Simon Eaton
May 21, 1986·Biochimica Et Biophysica Acta·S Kølvraa, N Gregersen
Feb 8, 1993·Biochimica Et Biophysica Acta·M Pourfarzam, K Bartlett
Jan 17, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·D GompertzT Baillie
Sep 25, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·S KølvraaN J Brandt
Feb 28, 1986·Biochimica Et Biophysica Acta·A C LanserJ B Ohlrogge
Oct 11, 1983·Biochimica Et Biophysica Acta·J H VeerkampV W Van Hinsbergh
Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·K Hamre, G van den Thillart
Jul 1, 1991·Metabolism: Clinical and Experimental·K Y TserngC L Hoppel
Jan 1, 1982·Archives of Biochemistry and Biophysics·B Davidson, H Schulz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.