The Role of Intermetal Competition and Mis-Metalation in Metal Toxicity

Advances in Microbial Physiology
Anna Barwinska-Sendra, Kevin J Waldron

Abstract

The metals manganese, iron, cobalt, nickel, copper and zinc are essential for almost all bacteria, but their precise metal requirements vary by species, by ecological niche and by growth condition. Bacteria thus must acquire each of these essential elements in sufficient quantity to satisfy their cellular demand, but in excess these same elements are toxic. Metal toxicity has been exploited by humanity for centuries, and by the mammalian immune system for far longer, yet the mechanisms by which these elements cause toxicity to bacteria are not fully understood. There has been a resurgence of interest in metal toxicity in recent decades due to the problematic spread of antibiotic resistance amongst bacterial pathogens, which has led to an increased research effort to understand these toxicity mechanisms at the molecular level. A recurring theme from these studies is the role of intermetal competition in bacterial metal toxicity. In this review, we first survey biological metal usage and introduce some fundamental chemical concepts that are important for understanding bacterial metal usage and toxicity. Then we introduce a simple model by which to understand bacterial metal homeostasis in terms of the distribution of each essenti...Continue Reading

Citations

Jun 13, 2017·Metallomics : Integrated Biometal Science·Hualiang Pi, John D Helmann
Mar 14, 2018·Gut Microbes·Joseph P Zackular, Eric P Skaar
Mar 10, 2020·Metallomics : Integrated Biometal Science·Nur SelamogluFevzi Daldal
Apr 25, 2020·Molecular Microbiology·Andrea Giachino, Kevin J Waldron
Jun 20, 2020·Microbial Biotechnology·Anne Soisig SteunouSoufian Ouchane
Jan 9, 2019·Frontiers in Molecular Neuroscience·Philipp O TsvetkovEvgeni Yu Zernii
Nov 18, 2018·Metallomics : Integrated Biometal Science·Emma TarrantKevin J Waldron
Nov 10, 2020·Metallomics : Integrated Biometal Science·Serena AmmendolaAndrea Battistoni
Jan 28, 2021·FEMS Microbiology Ecology·Andrea GiachinoKevin J Waldron
Feb 18, 2021·Proceedings of the National Academy of Sciences of the United States of America·Nicholas RaffaNancy P Keller
Aug 13, 2021·Critical Reviews in Food Science and Nutrition·Maoping DuanTuo Zhang
Aug 21, 2021·Metallomics : Integrated Biometal Science·Kaitlin Casanova-HamptonSargurunathan Subashchandrabose
Jun 8, 2021·Molecular Microbiology·Ankita J SachlaJohn D Helmann

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