The role of interstitial Cajal-like cells in the formation of cholesterol stones in guinea pig gallbladder

Hepatology International
Ying FanXin-Peng Wang

Abstract

To investigate the effect of interstitial Cajal-like cells (ICLCs) on contraction of gallbladder muscle strips; and to analyze the changes of ICLCs during cholesterol gallstone formation in guinea pig. The cholesterol gallstone animal model was made by feeding guinea pig with high cholesterol diet (HCD). In vitro isolated gallbladder muscle strips were prepared. Gallbladder motility was assessed by the contraction frequency and amplitude of slow wave in response to CCK-8. The alteration in ICLC density was estimated by using immunohistochemistry. The expression of c-kit and stem cell factor (SCF) were determined. The amplitude and frequency of slow wave was significantly lower in gallbladder muscle strips with the impaired ICLCs. And it is correlated with the decreased contractile response to CCK-8. In HCD guinea pig, the ICLC density and bile flow in response to CCK-8 were remarkably decreased. The results indicated that gallbladder ICLCs can create slow wave potential, and also get involved in the regulation of CCK-8 induced gallbladder smooth muscle motility. In the process of cholesterol gallstone formation, ICLC density clearly decreased. This further impaired gallbladder motility. The decrease in ICLC density may result f...Continue Reading

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Citations

Apr 28, 2018·Journal of Cellular and Molecular Medicine·Lei Chen, Baoping Yu
Apr 25, 2020·Journal of Cellular Physiology·Zhen-Peng HuangBao-Ping Yu
Sep 17, 2020·Expert Review of Gastroenterology & Hepatology·Yingyu LiuShuodong Wu
Jun 20, 2020·World Journal of Gastrointestinal Surgery·Bei-Bei FuYing Fan
May 29, 2021·World Journal of Clinical Cases·Bei-Bei FuYing Fan
Jun 17, 2021·Experimental and Therapeutic Medicine·Lei HuangXinmin Si

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