The role of interstitial infiltrates in IgA nephropathy: a study with monoclonal antibodies

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
E AlexopoulosJ S Cameron

Abstract

The leucocyte subpopulations in the interstitium and the glomeruli in renal biopsies from 34 patients with IgA nephropathy were analysed using monoclonal antibodies and immunoperoxidase techniques. Monocyte/macrophages and T-cells constituted the predominant infiltrating cell type in the interstitium (278 +/- 24 and 269 +/- 37 cells/mm2 respectively). Few intraglomerular leucocytes were seen, the majority of them belonging to the monocyte/macrophage phenotype (1.1 +/- 0.1 cells/glomerular cross-section). CD4+ lymphocytes predominated among the interstitial and glomerular T-cell populations and the CD4:CD8 ratio was 2.1 +/- 1.1 and 2.4 +/- 1.5 respectively. Only small numbers of NK cells and B cells were found in the interstitium, and almost none in the glomeruli. In contrast, significantly increased numbers of DR-expressing interstitial cells were seen (487 +/- 29/mm2), whereas DR expression by the tubular cells was minimal (37 +/- 6/mm2). Numbers of total leukocytes and T-cells were well correlated with the degree of tubulointerstitial damage and there was a significant correlation between renal functional impairment at the time of biopsy and the numbers of interstitial T cells (P less than 0.05) and CD4+ T cells (P less than ...Continue Reading

Citations

May 1, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J S Cameron
Sep 24, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sigrid LundbergStefan H Jacobson
Aug 1, 1993·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·G J Becker, P Kincaid-Smith
Feb 10, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Oliver M SteinmetzRolf A K Stahl
Sep 3, 1991·Klinische Wochenschrift·G A MüllerH P Rodemann
Mar 21, 2009·Current Opinion in Nephrology and Hypertension·Candice A Roufosse, H Terence Cook
May 18, 2006·Renal Failure·Guozhen ZhuDavid C H Harris
Apr 12, 2019·Frontiers in Immunology·Jan-Eric TurnerAndrew J Kassianos
Sep 1, 1996·Renal Failure·E Alexopoulos
Jan 1, 1996·Journal of Clinical Pathology·A H LeeD R Davies
Jan 5, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Aikaterini A PapagianniMenelaos Papadimitriou
May 21, 2010·American Journal of Physiology. Renal Physiology·Ka Ying TamKar Neng Lai
Sep 13, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Scott TaylorAthanasios Didangelos
Apr 4, 2021·Cells·Solange MollMarco Prunotto
Jan 5, 2000·Journal of the American Society of Nephrology : JASN·Ryuji OhashiNobuaki Yamanaka
Jun 26, 2001·Kidney International·A F El-KoraieA M El Nahas
Mar 13, 2003·Kidney International·Patricia G VallésMaria Rüttler
Dec 17, 2003·Kidney International·Efstathios Alexopoulos
Jul 15, 2005·Kidney International·Kevin Sean Eardley, Paul Cockwell
Jun 1, 1994·Kidney International·D Kees-FoltsG F Schreiner
Jul 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G D'AmicoM P Rastaldi
Mar 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E AlexopoulosM Papadimitriou
Dec 9, 1998·Kidney International·T Ehara, H Shigematsu
Jul 14, 2010·Seminars in Nephrology·Jeremy S Duffield
Jan 1, 1990·Kidney International·E AlexopoulosJ S Cameron

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.