The role of intracerebroventricular administration of leptin in the stimulation of prothyrotropin releasing hormone neurons in the hypothalamic paraventricular nucleus

Endocrinology
Mario PerelloEduardo A Nillni

Abstract

We previously have shown that leptin regulates proTRH in the paraventricular nucleus (PVN) of the hypothalamus through two pathways. The first one acts directly on proTRH neurons, and the second one (indirect) acts through the melanocortin system (arcuate nucleus). However, it is unknown whether the direct or the indirect pathways of leptin action on proTRH neurons occurs on separated or on the same subsets of neurons within the PVN region. We used immunostaining for the phosphorylated signal transducer and activator of transcription 3 to localize direct leptin signaling, and the phosphorylated cAMP response element binding protein to localize indirect signaling on proTRH neurons in animals intracerebroventricularly injected with leptin. With this approach we were able to identify two subsets of neuronal populations responsive to leptin, which are distributed in different regions within the PVN. ProTRH neurons directly responsive to leptin were located mainly in the medial and posterior part of the PVN, and they were not primarily related to the hypothalamic pituitary thyroid axis. Whereas, proTRH neurons indirectly responsive (through alpha-MSH) to leptin were located mainly in the anterior, medial, and periventricular part of...Continue Reading

Citations

Jul 20, 2007·Reviews in Endocrine & Metabolic Disorders·Gwendolyn W Louis, Martin G Myers
Feb 15, 2012·Molecular Neurobiology·Masoud Ghamari-Langroudi
May 14, 2008·The Journal of Biological Chemistry·Mario PerelloEduardo A Nillni
Sep 21, 2013·Omics : a Journal of Integrative Biology·Manish Kumar GuptaKrishna Misra
Feb 19, 2008·Thyroid : Official Journal of the American Thyroid Association·Anthony N Hollenberg
Jan 30, 2008·Thyroid : Official Journal of the American Thyroid Association·Anita BoelenEric Fliers
Sep 23, 2010·American Journal of Physiology. Endocrinology and Metabolism·Mario PerelloEduardo A Nillni
Mar 1, 2012·PloS One·Agustina CabralMario Perello
Mar 2, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiaobing Zhang, Anthony N van den Pol
Dec 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Masoud Ghamari-LangroudiRoger D Cone
Jul 10, 2014·European Journal of Endocrinology·Eric FliersAnita Boelen
Jul 11, 2014·Journal of Chemical Neuroanatomy·M M H van SwietenG van der Plasse
Jan 17, 2013·American Journal of Physiology. Endocrinology and Metabolism·Nicole E CyrEduardo A Nillni
Sep 25, 2012·Molecular and Cellular Endocrinology·Franck ChiappiniAnthony N Hollenberg
Jun 4, 2011·Journal of Physiological Anthropology·Huanjiu XiLiguang Zhao
Sep 20, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Liese Mebis, Greet Van den Berghe
Dec 17, 2014·Frontiers in Endocrinology·Cristiane Fonte Ramos, Ariane Zamoner
Jan 8, 2015·The Journal of Endocrinology·Patricia Joseph-BravoJean-Louis Charli
Apr 23, 2019·Annals of the New York Academy of Sciences·Raoni C Dos-SantosAndré S Mecawi
Jan 18, 2007·American Journal of Physiology. Endocrinology and Metabolism·María S LandaCarlos J Pirola
Jan 18, 2007·American Journal of Physiology. Endocrinology and Metabolism·Mario PerelloEduardo A Nillni
Apr 9, 2019·The Journal of Endocrinology·María F AndreoliMario Perello
Apr 4, 2021·International Journal of Molecular Sciences·Yunseon JangGi Ryang Kweon
Apr 11, 2021·Experimental & Molecular Medicine·Eun-Seon YooJong-Woo Sohn
Nov 9, 2021·Frontiers in Endocrinology·Marco Antonio Parra-Montes de OcaPatricia Joseph-Bravo

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