The role of invariant NKT cells in liver transplant tolerance in rats

Transplantation Proceedings
Y LiuM Li

Abstract

The aim of this study was to investigate the role of invariant natural killer T (iNKT) cells in liver transplant tolerance in rats. Animals were randomly divided into 3 groups. The α-galactosylceramide (α-GalCer) group underwent injection through the caudal vein; the saline group received the same dose of saline and the control group received no treatment. Ten rats in each group were examined for survival the others were humanely killed on the seventh day posttransplantation. Liver tissues were used to assess histopathologic changes. Real-time polymerase chain reaction (PCR) was performed to determine the relative expressions of messanger RNAs of Th1/Th2-related cytokine (mRNAs) in the liver allograft. The serum levels of related cytokines were determined using enzyme-linked immunosorbent assay (ELISA). Allograft survival was significantly higher among the α-galactosylceramide α-GalCer group than the saline or control groups. The histopathology showed mild changes in the α-galactosylceramide α-GalCer compared with the other 2 groups. Real-time PCR showed the relative expression of Th1-related cytokine interferen (IFN)-γ mRNA to be significantly lower in the α-galactosylceramide α-GalCer compared with the other 2 groups, while t...Continue Reading

References

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Jun 8, 2011·The Journal of Experimental Medicine·Dale Ian Godfrey, Jamie Rossjohn

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Citations

Nov 7, 2015·Journal of Immunology Research·Priscila de Matos SilvaPatricia Ucelli Simioni

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