The role of ion channels in malignant brain tumors

Journal of Neuro-oncology
Ole J SimonSven G Meuth

Abstract

Malignant gliomas are the most common primary brain tumors and have poor clinical prognosis, despite multimodal therapeutic strategies. In recent years, ion channels have emerged as major players in tumor pathophysiology regarding all hallmarks of cancer. Since ion channels are easily accessible structures, they may prove to be effective targets for canner therapy, although their broad expression pattern and role in physiological processes should be taken into consideration. This review summarizes the current knowledge on the role of ion channels in the pathophysiology of malignant gliomas, especially glioblastoma, and evaluates their potential role in targeted antiglioma therapy.

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Citations

Oct 16, 2019·The Journal of Physiology·Katrina A BlackJacqueline M Gulbis
Dec 12, 2018·MAbs·Catherine J HutchingsTheodore G Clark
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Oct 4, 2020·Molecular Cancer Therapeutics·Takeshi TakayasuLeomar Y Ballester
Jan 10, 2021·International Journal of Molecular Sciences·Jaroslaw SzczepaniakMarta Grodzik

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