The role of iron neurotoxicity in ischemic stroke

Ageing Research Reviews
Magdy H Selim, Rajiv R Ratan

Abstract

Stroke is the second leading cause of death worldwide, and its incidence is expected to rise with the projected increase in the number of aging population. Disturbances of brain iron homeostasis have been linked to acute neuronal injury following cerebral ischemia. Free iron catalyzes the conversion of superoxide and hydrogen peroxide into hydroxyl radicals, which promote oxidative stress leading to subsequent cell death/apoptosis. In recent years, considerable evidence has emerged regarding the role of iron neurotoxicity following experimental cerebral ischemia. Few clinical studies have also attempted to investigate the role of iron in stroke patients. The present review will examine the currently available evidence for iron-mediated neurotoxicity and the potential mechanisms underlying deregulation of iron homeostasis in the brain following cerebral ischemia. Understanding the changes in brain iron metabolism and its relationship to neuronal injury in ischemic stroke could provide new therapeutic targets to improve the outcome of stroke patients.

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References

Jan 1, 1992·Free Radical Biology & Medicine·D W Reif
Aug 15, 1992·Journal of Inorganic Biochemistry·C M MorrisJ A Edwardson
Aug 1, 1992·Surgical Neurology·D S SoloniukJ R Wilson
Jan 1, 1991·European Neurology·M B YoudimP Riederer
Jul 1, 1991·Journal of Neurochemistry·W P BartlettJ R Connor
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C N OliverR A Floyd
Dec 1, 1990·Journal of Neuroscience Research·J R ConnorE J Mufson
Feb 1, 1990·Journal of Pediatric Surgery·A PattJ E Repine
Jan 1, 1986·The International Journal of Biochemistry·M MulliganM C Linder
Mar 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y KondoA Mori
Jun 1, 1994·Free Radical Biology & Medicine·M OubidarJ Bralet
Apr 21, 1994·The New England Journal of Medicine·A Ascherio, W C Willett
May 1, 1994·Stroke; a Journal of Cerebral Circulation·C PalmerC Bero
May 14, 1993·Neuroscience Letters·A GochtC M Morris
Jul 12, 1993·FEBS Letters·C Rice-EvansJ Wrigglesworth
May 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y ZhangM P Mattson
Dec 1, 1995·Toxicology Letters·C C Winterbourn
Nov 5, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E ShohamiR Kohen
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·K D Poss, S Tonegawa
Feb 24, 1998·Stroke; a Journal of Cerebral Circulation·K C JohnstonE C Haley
Feb 24, 1998·Stroke; a Journal of Cerebral Circulation·D C LipscombP D Hurn
Sep 11, 1998·BMJ : British Medical Journal·J T SalonenK Punnonen
Nov 20, 1998·Journal of Neuroscience Research·T Moos, E H Morgan
Apr 23, 1999·Journal of Neuroscience Research·C PalmerJ R Connor
Jul 27, 1999·Archives of Internal Medicine·B de Valk, J J Marx
Jan 10, 2002·Neurology·H B van der WorpUNKNOWN TESS II Investigators
Oct 29, 2002·Developmental Neuroscience·Evan H Morgan, Torben Moos
Nov 26, 2002·Annals of Neurology·Chelsea S KidwellJeffry R Alger

❮ Previous
Next ❯

Citations

Feb 3, 2009·Cell Biochemistry and Biophysics·Nathan R Perron, Julia L Brumaghim
Nov 14, 2007·Neuromolecular Medicine·Frank HabermanMark P Mattson
Jul 9, 2011·Nature Medicine·Costantino Iadecola, Josef Anrather
Oct 18, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K-H ChoiK-H Cho
Jun 11, 2009·The Journal of Pharmacology and Experimental Therapeutics·Leah R HansonS Scott Panter
Oct 25, 2013·Nutrients·Rahul G Sangani, Andrew J Ghio
Dec 4, 2013·Journal of Neurotrauma·Eric J NisenbaumYvonne W Lui
Jul 8, 2009·Neurochemical Research·Carlo AldinucciGian Paolo Pessina
Jan 25, 2014·Brain Injury : [BI]·Roberto AquilaniFederica Boschi
Aug 15, 2009·Experimental Neurology·Xin Zhang, Weidong Le
Feb 13, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Amy C Y LoSookja K Chung
Dec 17, 2015·Biological Trace Element Research·Lydmila L KlimenkoAlexandr A Nikonorov
Nov 18, 2005·Journal of Biochemical and Molecular Toxicology·Wissam Ibrahim, Ching Kuang Chow
Jan 6, 2009·Journal of Cellular and Molecular Medicine·Noemi MorelloEmanuela Tolosano
Apr 8, 2014·CNS Neuroscience & Therapeutics·Gabriella MifsudMario Valentino
Sep 6, 2005·Free Radical Biology & Medicine·Antonio CherubiniPatrizia Mecocci
Apr 5, 2012·Ultrastructural Pathology·Boguslaw LipinskiWendy J van der Spuy
May 18, 2013·Neurotoxicology·E ChouraquiD Duval
Jan 27, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Giovanna RassuAlessandro Dalpiaz
Feb 7, 2012·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Mirella BoselliFederica Boschi
Jul 21, 2017·The International Journal of Neuroscience·Guanfeng LuFei Cao
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Junpeng MaLi Hao
Jan 12, 2013·Stroke; a Journal of Cerebral Circulation·Joanna KaluzaSusanna C Larsson
Dec 2, 2006·Stroke; a Journal of Cerebral Circulation·Mónica MillanAntonio Dávalos
Feb 25, 2011·The Journal of Nutrition·Wint Nandar, James R Connor
Aug 8, 2020·Journal of Neural Engineering·Nicholas V ApolloFlavia Vitale
Apr 4, 2007·Neurochemical Research·Julie A GaaschCornelis J Van der Schyf
Mar 27, 2018·Biological Reviews of the Cambridge Philosophical Society·Douglas B Kell, Etheresia Pretorius
Jun 15, 2018·Frontiers in Neurology·Rosanna SquittiFranca Tecchio
Jul 1, 2017·Aging Clinical and Experimental Research·Joanna FrąckiewiczJoanna Kałuża

❮ Previous
Next ❯

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