The role of kidney transplantation and phosphate binder use in vitamin K status

PloS One
Thijs T JanszBrigit C van Jaarsveld

Abstract

Cardiovascular disease is the leading cause of death in end-stage renal disease and is strongly associated with vascular calcification. Both kidney transplantation and phosphate binders may lower the risk of vascular calcification. Vascular calcification is actively inhibited by vitamin-K-dependent matrix γ-carboxyglutamic acid protein (MGP). Whether kidney transplantation or phosphate binders affect vitamin K status is unknown. Therefore, we studied the influence of kidney transplantation and phosphate binder use on vitamin K status. We measured plasma desphospho-uncarboxylated MGP (dp-ucMGP), a marker reflecting low vitamin K status, in a cross-sectional study of patients on hemodialysis (n = 82), peritoneal dialysis (n = 31) or who recently received a kidney transplantation (n = 36). By medication inventory, we assessed phosphate binder use. With linear regression, we assessed the influence of kidney transplantation and phosphate binder use on natural-log-transformed dp-ucMGP, adjusting for potential confounders. Mean age of patients was 52±13 years; 102 (68%) were male. Dp-ucMGP levels were significantly lower in kidney transplant recipients (median 689 pmol/L) compared to patients on dialysis (median 1537 pmol/L, p<0.001)....Continue Reading

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Citations

Dec 21, 2019·Journal of Nephrology·Maria FusaroPascale Khairallah
Mar 19, 2020·Toxins·Anika HimmelsbachClaudia Goettsch
Jun 4, 2020·Nutrients·Mario CozzolinoGaetano La Manna
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Nov 1, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Aegida NeradovaLeon J Schurgers

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Methods Mentioned

BETA
coronary
peripheral artery angioplasty

Clinical Trials Mentioned

NCT00950573

Software Mentioned

R
R Foundation Statistical Computing
NOCTx

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