The role of kinesin KIF18A in the invasion and metastasis of hepatocellular carcinoma

World Journal of Surgical Oncology
Weiwei LuoWeijia Liao

Abstract

KIF18A is associated with a variety of tumours; however, the specific mechanism of action of KIF18A in hepatocellular carcinoma (HCC) remains unclear. In this study, in vitro and in vivo experiments were performed with the aim of exploring the potential function and molecular mechanism of kinesin KIF18A in the occurrence and development of HCC. We detected the expression of KIF18A in tumour and adjacent tissues as well as cell proliferation, cell invasion and migration in hepatoma cells after silencing KIF18A. KIF18A-silenced hepatoma cells were subcutaneously injected into nude mice to verify the tumorigenicity of KIF18A. We also detected the expression of signal pathway-related proteins in hepatoma cells after KIF18A knockdown with the aim of exploring the association between KIF18A and related signalling pathways. The level of KIF18A protein was higher in liver cancer tissues than adjacent tissues. After silencing KIF18A in SMMC-7721 and HepG2 cells, cell growth was obviously inhibited; the migration and invasion abilities were significantly decreased and the in vivo tumour weight was decreased compared to the control group (0.201 ± 0.088 g vs 0.476 ± 0.126 g, p = 0.009). The expression of cell cycle-related protein (cyclin ...Continue Reading

References

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Citations

Aug 29, 2018·Environmental and Molecular Mutagenesis·Xiang WanShao-Chen Sun
Apr 8, 2020·Journal of Cellular and Molecular Medicine·Yong-Bin ChoYoung-Jin Seo
Apr 20, 2021·Biochemical and Biophysical Research Communications·Lu-Xi QianLi Yin

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Methods Mentioned

BETA
PCR
transfection
electrophoresis
X-ray
surgical resection

Software Mentioned

SPSS

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