The role of kinins in the antihypertensive and cardioprotective effects of ACE inhibitors

Drugs
G Bönner

Abstract

Kinins are highly potent vasoactive peptides. They reduce blood pressure by vasodilation and are cardio- and vasoprotective. ACE inhibitors potentiate the actions of endogenous kinins by about 50-fold. Kinins are involved in the blood pressure-lowering effects of ACE inhibitors in all forms of hypertension associated with stimulation of the renin-angiotensin system. In addition, kinins play an important role in the metabolic, and cardio- and vasoprotective effects of ACE inhibitors.

Citations

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Mar 15, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C I RipamontiM Fallon
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