The Role of Kiss1 Neurons As Integrators of Endocrine, Metabolic, and Environmental Factors in the Hypothalamic-Pituitary-Gonadal Axis

Frontiers in Endocrinology
Shel-Hwa Yeo, William H Colledge

Abstract

Kisspeptin-GPR54 signaling in the hypothalamus is required for reproduction and fertility in mammals. Kiss1 neurons are key regulators of gonadotropin-releasing hormone (GnRH) release and modulation of the hypothalamic-pituitary-gonadal (HPG) axis. Arcuate Kiss1 neurons project to GnRH nerve terminals in the median eminence, orchestrating the pulsatile secretion of luteinizing hormone (LH) through the intricate interaction between GnRH pulse frequency and the pituitary gonadotrophs. Arcuate Kiss1 neurons, also known as KNDy neurons in rodents and ruminants because of their co-expression of neurokinin B and dynorphin represent an ideal hub to receive afferent inputs from other brain regions in response to physiological and environmental changes, which can regulate the HPG axis. This review will focus on studies performed primarily in rodent and ruminant species to explore potential afferent inputs to Kiss1 neurons with emphasis on the arcuate region but also considering the rostral periventricular region of the third ventricle (RP3V). Specifically, we will discuss how these inputs can be modulated by hormonal, metabolic, and environmental factors to control gonadotropin secretion and fertility. We also summarize the methods and ...Continue Reading

References

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Citations

Feb 29, 2020·Molecular Reproduction and Development·Jing QiuJian Yu
Jan 5, 2019·Clinical and Experimental Pharmacology & Physiology·Aleksandra Suszka-ŚwitekRyszard Wiaderkiewicz
May 7, 2020·The European Journal of Neuroscience·Pablo Nicolás SurkinJavier Fernández-Solari
Jun 4, 2020·International Journal of Molecular Sciences·Francesca SciarraMary Anna Venneri
Sep 21, 2020·General and Comparative Endocrinology·Rosaria MeccarielloRiccardo Pierantoni
Sep 22, 2020·Molecular and Cellular Endocrinology·Dor Shalev, Philippa Melamed
Aug 31, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·María B RabaglinoHaja N Kadarmideen
Sep 9, 2021·The Journal of Obstetrics and Gynaecology Research·Aki OrideSatoru Kyo
Nov 18, 2021·The Journal of Experimental Biology·Laura van Rosmalen, Roelof A Hut
Jan 4, 2022·The Journal of Obstetrics and Gynaecology Research·Takeshi IwasaKanako Yoshida

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Methods Mentioned

BETA
reverse-transcription PCR
reverse transcription-PCR
scRNA-seq
transgenic
electron microscopy
affinity purification
PCR

Software Mentioned

vTRAP

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