The role of Kupffer cells in the hepatic response to silver nanoparticles

Nanotoxicology
Ali KermanizadehVicki Stone

Abstract

Engineered nanoparticles are increasingly used in medical applications and day-to-day consumer products, leading to concerns about the potential environmental and human health impacts. Silver nanoparticles are particularly prevalent because of their use as anti-bacterial agents in many commonly available products. Nanoparticles (NPs) are believed to accumulate, often preferentially, in the liver. This study therefore investigates the effect of a silver NP (20 nm) on the liver, and in particular, the role of Kupffer cells (KCs; resident liver macrophages) in the overall inflammatory response in the organ. Cytokine expression in the normal liver was measured in terms of IL2, IL4, TNF-α, IFN-γ and IL10 released from the organ with significant up-regulation of TNF-α and IL10 being observed. For livers in which the KC population was specifically targeted and destroyed this cytokine increase was significantly decreased in comparison to the normal tissue. IL10 was secreted at approximately three times the concentration of TNF-α in all the test cases. The high levels of IL10 released from the normal tissue in comparison to the KC depleted livers suggest that the cytokine may help to protect against a pro-inflammatory response to these ...Continue Reading

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Citations

Mar 11, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Jin-Kyu ParkYasuko Iwakiri
Aug 8, 2014·Archives of Toxicology·Esther BeladeJorge Boczkowski
Apr 30, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ali KermanizadehPeter Møller
Apr 24, 2020·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Ali KermanizadehVicki Stone
Jul 6, 2016·Nanotechnology·Kalpana MahadevanRamjee Balasubramanian
Feb 25, 2017·Advanced Healthcare Materials·Shasha ZhuLongping Wen
Oct 9, 2020·Journal of Applied Toxicology : JAT·Subhayu NayekGuido F Verbeck

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