The role of "leakage" of tubular fluid in anuria due to mercury poisoning

The Journal of Clinical Investigation
N BankH S Aynedjian

Abstract

The role of "leakage" of tubular fluid in anuria produced by mercury poisoning was studied in rats by micropuncture techniques. After an initial brisk diuresis, almost all animals were completely anuric 24 hours after HgCl(2) injection. Lissamine green injected intravenously in the early stage of anuria appeared in the beginning of the proximal tubule, but the color became progressively lighter as the dye traversed the proximal convolutions. The dye was barely visible in the terminal segments of the proximal tubule; it did not appear at all in the distal tubules. These observations suggest that the proximal epithelium had become abnormally permeable to Lissamine green. Tubular fluid to plasma inulin (TF/P(In)) ratios and inulin clearance were measured in individual nephrons at three sites: early proximal tubule, late proximal tubule, and distal tubule. It was found that TF/P(In) ratios were abnormally low in the late proximal and distal tubules. Inulin clearance was normal at the beginning of the proximal tubule but fell by more than 60% by the late proximal convolutions. Thus, the proximal tubule had also become permeable to inulin. We conclude from these observations that anuria in mercury poisoning can occur in the presence ...Continue Reading

References

May 1, 1953·Medicine·R C SWANN, J P MERRILL
May 31, 1956·The New England Journal of Medicine·J T FINKENSTAEDT, J P MERRILL
May 1, 1964·The American Journal of Medicine·G GIEBISCH, E E WINDHAGER
Jul 1, 1964·The Journal of General Physiology·G GIEBISCHE E WINDHAGER
Mar 1, 1965·The Journal of Clinical Investigation·W J FLANIGAN, D E OKEN
Sep 1, 1965·The Journal of Clinical Investigation·W SUKID W SELDIN

❮ Previous
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Citations

Jan 31, 1978·Pflügers Archiv : European journal of physiology·J MasonK Thurau
Jul 19, 1977·Pflügers Archiv : European journal of physiology·B R Edwards, P Stern
Jan 1, 1973·Pflügers Archiv : European journal of physiology·G M Eisenbach, M Steinhausen
Jan 1, 1969·Pflügers Archiv : European journal of physiology·M SteinhausenV Helmstädter
Jul 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J E Bird, R C Blantz
Jun 15, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·M WernerR Nayar
Jan 1, 1971·Transactions of the Royal Society of Tropical Medicine and Hygiene·A P MukherjeeK S Lau
Jun 11, 1970·The New England Journal of Medicine·N K HollenbergJ P Merrill
Jun 11, 1970·The New England Journal of Medicine·L E Earley
Oct 17, 1974·The New England Journal of Medicine·R A GrossmanM Goldberg
Jun 23, 1977·The New England Journal of Medicine·N G Levinsky
Jan 1, 1976·Journal of Toxicology and Environmental Health·W O Berndt
Sep 1, 1976·Journal of Toxicology and Environmental Health·W O Berndt
Jul 29, 1975·European Journal of Clinical Investigation·S B Russell
Jan 31, 1970·British Medical Journal·J J BrownJ I Robertson
Jun 1, 1979·Postgraduate Medical Journal·K S ChughA K Sarkar
Jul 1, 1968·The Journal of Clinical Investigation·K M KochN Bank
Apr 1, 1970·The Journal of Clinical Investigation·D E OkenF D McDonald
Jun 1, 1972·The Journal of Clinical Investigation·U F MichaelS Papper
Jun 1, 1974·The Journal of Clinical Investigation·J W CoxT F Ferris
Mar 1, 1975·The Journal of Clinical Investigation·R C Blantz
Jun 1, 1976·Environmental Health Perspectives·D E Oken
Sep 1, 1971·The British Journal of Radiology·R A BranchE Lowder
Dec 12, 1978·Virchows Archiv. A, Pathological Anatomy and Histology·M SteinhausenA Schwaier
Jan 20, 1977·Virchows Archiv. A, Pathological Anatomy and Histology·H D ZimmermannP Dieker
Nov 1, 1971·The Journal of Clinical Investigation·M M PopovtzerC R Kleeman
Jan 1, 1987·Journal of Toxicology. Clinical Toxicology·K S Merigian, J R Roberts
Jul 1, 1982·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H D HumesT C Knauss
Dec 1, 1989·Kidney International·O W PetersonR C Blantz
Aug 1, 1987·Kidney International·A I WolfertD E Oken
Feb 1, 1979·Kidney International·R W Schrier
Apr 1, 1977·Kidney International·S ChurchillD E Oken
Jan 1, 1982·Kidney International·S ChopraB F Trump
Dec 1, 1982·Kidney International·J T ChengW E Yarger
Jun 1, 1983·Kidney International·N Honda
Mar 1, 1993·Kidney International·N Honda, A Hishida
Jul 1, 1975·Kidney International·J H SteinT F Ferris
Dec 1, 1975·Kidney International·R C UffermanR C Pabico

❮ Previous
Next ❯

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