PMID: 15333744Aug 31, 2004Paper

The role of leptin in regulating neuroendocrine function in humans

The Journal of Nutrition
Susann Blüher, Christos S Mantzoros

Abstract

Eating disorders are a group of disease states including anorexia nervosa, bulimia nervosa and binge eating on one end as well as episodic or chronic overeating resulting in obesity at the other end of the spectrum. These disorders are characterized by decreased and/or increased energy intake and are frequently associated with hormonal and metabolic disorders. The discovery of leptin, an adipocyte-secreted hormone acting in the brain to regulate energy homeostasis, and its subsequent study in human physiology have significantly advanced our understanding of normal human physiology and have provided new opportunities for understanding and possibly treating disease states, such as anorexia and bulimia nervosa. It has been recently discovered that leptin levels above a certain threshold are required to activate the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-thyroid axes in men, whereas the hypothalamic-pituitary-adrenal, renin-aldosterone, and growth hormone-IGF-1 axes may be largely independent of circulating leptin levels in humans. In this review, we summarize the latest findings related to the role of leptin in the regulation of several neuroendocrine axes, such as the hypothalamic-pituitary-gonadal and the hypo...Continue Reading

References

Jan 27, 1977·The New England Journal of Medicine·R M BoyarD K Fukushima
Mar 3, 1977·Nature·P TrayhurnW P James
Jan 1, 1977·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·P U Dubuc
Jun 1, 1976·Endocrinology·R S SwerdloffG A Bray
Oct 1, 1988·BMJ : British Medical Journal·T CantopherJ M Pearce
Dec 16, 1995·Lancet·J HebebrandW Herzog
Dec 29, 1995·Cell·L A TartagliaR I Tepper
Feb 2, 1996·The Journal of Biological Chemistry·P LeroyC Dani
Jul 18, 1996·Nature·R S AhimaJ S Flier
Nov 21, 1996·Biochemical and Biophysical Research Communications·M K SinhaJ F Caro
Feb 1, 1997·The Journal of Clinical Investigation·R S AhimaJ S Flier
Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·W H YuS M McCann
Mar 7, 1997·The Journal of Biological Chemistry·L A Tartaglia
May 8, 1997·Nature·F ZhangR W Schevitz
Jun 1, 1997·Molecular Human Reproduction·J A CioffiH R Snodgrass
Mar 4, 1998·Proceedings of the National Academy of Sciences of the United States of America·J LicinioP W Gold
Mar 21, 1998·Nature Genetics·A StrobelA D Strosberg
May 20, 1998·The Journal of Clinical Endocrinology and Metabolism·S M Smith-KirwinV L Funanage
Jul 11, 1998·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·W KöppJ Hebebrand
Sep 2, 1998·Nature·A BadoM J Lewin
Dec 9, 1998·General and Comparative Endocrinology·E Terasawa
Dec 19, 1998·Molecular Psychiatry·L AudiA Carrascosa
Jan 23, 1999·Biology of Reproduction·M J CunninghamR A Steiner
Apr 24, 1999·Annals of Internal Medicine·C S Mantzoros
Apr 27, 1999·Biochimica Et Biophysica Acta·N AokiT Matsuda
Apr 30, 1999·Journal of Psychiatric Research·R K StøvingC Hagen
May 20, 1999·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·K MathiakW Köpp
Sep 16, 1999·The New England Journal of Medicine·I S FarooqiS O'Rahilly

❮ Previous
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Citations

Jul 6, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T ReinehrW Andler
May 26, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Grazyna Bednarek-TupikowskaAndrzej Milewicz
Jun 30, 2010·Journal of Pediatric Endocrinology & Metabolism : JPEM·Artur BossowskiBeata Zelazowska-Rutkowska
Jul 28, 2011·American Journal of Physiology. Endocrinology and Metabolism·Christos S MantzorosAnastasia Koniaris
Oct 8, 2013·The Journal of Endocrinology·Anna H KongstedMette O Nielsen
Nov 8, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Carol F Elias
Oct 22, 2015·The Journal of Endocrinology·Russell T TurnerUrszula T Iwaniec
Mar 10, 2017·European Eating Disorders Review : the Journal of the Eating Disorders Association·Jessica H BakerJoyce T Bromberger
Apr 17, 2007·Arquivos brasileiros de endocrinologia e metabologia·Sandra Maria Lima RibeiroJulio Tirapegui
Apr 6, 2012·PloS One·Linda Karlsson-LindahlSuzanne L Dickson
Apr 14, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Elzbieta PaszynskaAndrzej Rajewski
Jul 29, 2008·American Journal of Physical Anthropology·Patricia L Whitten, Trudy R Turner
Jan 29, 2008·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Blazej MeczekalskiAndrea Riccardo Genazzani
Feb 18, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Urszula T IwaniecSatya P Kalra
Mar 12, 2013·Endocrine Reviews·Hyun-Seuk MoonChristos S Mantzoros
Apr 8, 2020·BMC Endocrine Disorders·Preaw SuwannasrisukSarat Sunthornyothin
May 21, 2011·Psychosomatic Medicine·Melanie L Zupancic, Aman Mahajan
Sep 17, 2008·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Martin PetzelKristian Safarcik
Nov 6, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Susann Blüher, Christos S Mantzoros
Aug 9, 2011·The International Journal of Eating Disorders·Jiri BronskyRichard Prusa
Jun 28, 2012·Diabetes & Metabolism Journal·Christos S Mantzoros
Aug 1, 2020·International Journal of Molecular Sciences·Fatuma MeyerLuzia Valentini
Aug 16, 2011·Physiology & Behavior·Anja HilbertAndrea S Hartmann
Jun 20, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Gülten CingözGönül Çatlı
Dec 20, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Sanne Fisker

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