The Role of Leptin in the Association between Obesity and Psoriasis

Biomolecules & Therapeutics
Jaehyeon HwangJongsung Lee

Abstract

Adipose tissue secretes many adipokines which contribute to various metabolic processes, such as blood pressure, glucose homeostasis, inflammation and angiogenesis. The biology of adipose tissue in an obese individual is abnormally altered in a manner that increases the body's vulnerability to immune diseases, such as psoriasis. Psoriasis is considered a chronic inflammatory skin disease which is closely associated with being overweight and obese. Additionally, secretion of leptin, a type of adipokine, increases dependently on adipose cell size and adipose accumulation. Likewise, high leptin levels also aggravate obesity via development of leptin resistance, suggesting that leptin and obesity are closely related. Leptin induction in psoriatic patients is mainly driven by the interleukin (IL)-23/helper T (Th) 17 axis pathway. Furthermore, leptin can have an effect on various types of immune cells such as T cells and dendritic cells. Here, we discuss the relationship between obesity and leptin expression as well as the linkage between effect of leptin on immune cells and psoriasis progression.

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Citations

Jul 27, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Gashaw DessieMeseret Derbew Molla
Aug 10, 2021·Frontiers in Immunology·Yan HaoJiong Li
Aug 12, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Sara CheleschiAntonella Fioravanti

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