PMID: 708411Aug 15, 1978Paper

The role of lipid components of the diet in the regulation of the fatty acid composition of the rat liver endoplasmic reticulum and lipid peroxidation

The Biochemical Journal
C T Hammer, E D Wills

Abstract

The fatty acid compositions of the lipids and the lipid peroxide concentrations and rates of lipid peroxidation were determined in suspensions of liver endoplasmic reticulum isolated from rats fed on synthetic diets in which the fatty acid composition had been varied but the remaining constituents (protein, carbohydrate, vitamins and minerals) kept constant. Stock diet and synthetic diets containing no fat, 10% corn oil, herring oil, coconut oil or lard were used. The fatty acid composition of the liver endoplasmic reticulum lipid was markedly dependent on the fatty acid composition of the dietary lipid. Feeding a herring-oil diet caused incorporation of 8.7% eicosapentaenoic acid (C(20:5)) and 17% docosahexaenoic acid (C(22:6)), but only 5.1% linoleic acid (C(18:2)) and 6.4% arachidonic acid (C(20:4)), feeding a corn-oil diet caused incorporation of 25.1% C(18:2), 17.8% C(20:4) and 2.5% C(22:6) fatty acids, and feeding a lard diet caused incorporation of 10.3% C(18:2), 13.5% C(20:4) and 4.3% C(22:6) fatty acids into the liver endoplasmic-reticulum lipids. Phenobarbitone injection (100mg/kg) decreased the incorporation of C(20:4) and C(22:6) fatty acids into the liver endoplasmic reticulum of rats fed on a lard, corn-oil or her...Continue Reading

Citations

Mar 10, 2015·Life Sciences·Sandra Barbosa-da-SilvaCarlos Alberto Mandarim-de-Lacerda
Dec 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D JamiesonR Gibson
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Feb 27, 2008·Journal of Clinical Biochemistry and Nutrition·Seiji SekineMorio Saito
Jan 10, 2013·The British Journal of Nutrition·Sanjoy GhoshDeanna L Gibson
Sep 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J T LaMontJ R Moore
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