The Role of Lipid Metabolism for Neural Stem Cell Regulation

Brain Plasticity
Marlen Knobloch

Abstract

Neural stem/progenitor cells (NSPCs) give rise to billions of cells during development and are critical for proper brain formation. The finding that NSPCs persist throughout adulthood has challenged the view that the brain has poor regenerative abilities and raised hope for stem cell-based regenerative therapies. For decades there has been a strong movement towards understanding the requirements of NSPCs and their regulation, resulting in the discovery of many transcription factors and signaling pathways that can influence NSPC behavior and neurogenesis. However, the role of metabolism for NSPC regulation has only gained attention recently. Lipid metabolism in particular has been shown to influence proliferation and neurogenesis, offering exciting new possible mechanisms of NSPC regulation, as lipids are not only the building blocks of membranes, but can also act as alternative energy sources and signaling entities. Here I review the recent literature examining the role of lipid metabolism for NSPC regulation and neurogenesis.

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Citations

May 29, 2018·Journal of Neurochemistry·Mandana HunterMaurice A Curtis
Sep 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Amira NamsiGérard Lizard
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Jul 28, 2020·Frontiers in Cell and Developmental Biology·Antonela BonafinaFernanda Ledda
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Sep 5, 2019·International Journal of Molecular Sciences·Amanda Lo VanNathalie Bernoud-Hubac
Mar 24, 2021·Signal Transduction and Targeted Therapy·Zeyu WangQuan Cheng
Apr 4, 2021·International Journal of Molecular Sciences·Hansruedi Büeler

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Methods Mentioned

BETA
fatty acid
histone acetylation
fluorescence-activated cell sorting
nuclear magnetic resonance

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