The role of lipid microdomains in virus biology

Sub-cellular Biochemistry
Debi P Nayak, Eric K W Hui

Abstract

Many of the highly pathogenic viruses including influenza virus, HIV and others of world wide epidemiological importance are enveloped and possess a membrane around the nucleocapsid containing the viral genome. Viral membrane is required to protect the viral genome and provide important functions for attachment, morphogenesis and transmission. Viral membrane is essentially composed of lipids and proteins. While the proteins on the viral envelope are almost exclusively virally encoded, lipids, on the other hand, are all of host origin and recruited from host membrane. However, lipids on the viral membrane are not incorporated randomly and do not represent average lipid composition of the host membrane. Recent studies support that specific lipid microdomains such as lipid rafts play critical roles in many aspects of the virus infectious cycle including attachment, entry, uncoating, protein transport and sorting as well as viral morphogenesis and budding. Lipid microdomains aid in bringing and concentrating viral components to the budding site. Similarly, specific viral protein plays an important role in organizing lipid microdomains in and around the assembly and budding site of the virus. This review deals with the specific role...Continue Reading

Citations

Sep 20, 2006·Glycobiology·Sandro SonninoAlessandro Prinetti
Oct 17, 2019·Journal of Lipid Research·Michael I BukrinskyDmitri Sviridov
Apr 1, 2006·Glycoconjugate Journal·Mikhail MatrosovichHans-Dieter Klenk
Dec 23, 2011·Journal of Virology·Chikako KataokaYoshiharu Matsuura
Feb 6, 2017·Journal of Cell Science·Alexander LudwigRichard J Sugrue
May 11, 2011·Biology of the Cell·Julien PerinoAnne-Laure Favier
Mar 4, 2006·Experimental Biology and Medicine·Keli KolegraffAftab A Ansari
Sep 9, 2017·Archives of Virology·Ji Hyun Jeon, Changhee Lee
Jul 7, 2005·Proceedings of the National Academy of Sciences of the United States of America·Matthew I BonaparteChristopher C Broder
Dec 9, 2020·Biochemistry (Moscow) Supplement. Series A, Membrane and Cell Biology·A Ya Dunina-Barkovskaya, Kh S Vishnyakova
Jul 28, 2020·International Journal of Pharmaceutics·Pablo F GarridoRebeca Garcia-Fandino
Apr 24, 2007·Biophysical Journal·Laura WesselsKeith Weninger
Aug 26, 2021·Analytical Chemistry·Kyana Y GarzaAndreia M Porcari

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