PMID: 3319224Nov 1, 1987Paper

The role of lipid peroxidation in liver damage

Chemistry and Physics of Lipids
G PoliM U Dianzani

Abstract

The consequences of the peroxidative breakdown of membrane lipids have been considered in relation to both the subcellular and tissue aspects of liver injury. Mitochondrial functions can be impaired by lipid peroxidation probably through the oxidation of pyridine nucleotides and the consequent alteration in the uptake of calcium. Several enzymatic functions of the endoplasmic reticulum are also affected as a consequence of peroxidative events and among these are the activities of glucose 6-phosphatase, cytochrome P-450 and the calcium sequestration capacity. Moreover, a release of hydrolytic enzymes from lysosomes and a decrease in the fluidity of plasma membranes can contribute to the liver damage consequent to the stimulation of lipid peroxidation. Extensive studies carried out in vivo and integrated with the use of isolated hepatocytes have shown that lipid peroxidation impairs lipoprotein secretion mainly at the level of the dismission from the Golgi apparatus, rather than during their assembly. However, such an alteration appears to give a late and not essential contribution to the fat accumulation. A more critical role is played by peroxidative reactions in the pathogenesis of acute liver necrosis induced by several pro-o...Continue Reading

References

Nov 15, 1975·European Journal of Biochemistry·J HögbergS Orrenius
May 15, 1979·The Biochemical Journal·A BenedettiM Comporti
Jan 15, 1975·European Journal of Biochemistry·J HögbergR E Larson
Mar 15, 1977·European Journal of Biochemistry·J Högberg, A Kristoferson
Sep 30, 1979·Toxicology and Applied Pharmacology·R F Burk, J M Lane
Aug 15, 1978·The Biochemical Journal·T J Peters, C A Seymour
Sep 1, 1978·The Journal of Pathology·M V TorrielliM U Dianzani
Nov 1, 1978·Toxicology and Applied Pharmacology·D K AlbrechtH Remmer
Mar 1, 1975·Journal of Agricultural and Food Chemistry·P J O'brien, A Rahimtula
Jan 1, 1976·Annual Review of Pharmacology and Toxicology·G L Plaa, H Witschi
Sep 15, 1975·European Journal of Biochemistry·H Sies, K H Summer
Jan 1, 1986·Journal of Free Radicals in Biology & Medicine·S D Varma, J M Mooney
Jan 1, 1987·Free Radical Research Communications·U M MarinariM U Dianzani
Jan 1, 1986·Free Radical Research Communications·L Eklöw-LåstbomS Orrenius
Jan 3, 1986·Biochimica Et Biophysica Acta·G JürgensH Esterbauer
Jul 1, 1986·Toxicology and Applied Pharmacology·G F RushD Alberts
Jan 1, 1986·The International Journal of Biochemistry·A MomchilovaK Koumanov
Oct 1, 1986·Biochimica Et Biophysica Acta·N WatanabeS Yoshida
Dec 1, 1986·Biochemical Pharmacology·R J GersonJ L Farber
Jan 1, 1985·The Journal of Clinical Investigation·I T Mak, W B Weglicki
Jan 1, 1985·Cell Biochemistry and Function·R A CanutoM U Dianzani
May 1, 1985·Alcohol·A R ZeinerN Nichols
Sep 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B R BaconA S Tavill
May 1, 1985·Toxicology and Applied Pharmacology·G F RushW R Hewitt
Dec 31, 1985·Chemico-biological Interactions·L GabrielM U Dianzani
Dec 1, 1974·Toxicology·M V TorrielliE Burdino
Apr 1, 1968·Experimental and Molecular Pathology·S Hashimoto, R O Recknagel

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Citations

Jan 1, 1990·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·L A HashimotoS Matsuno
Feb 1, 1991·Cytotechnology·G Bellomo
Aug 1, 1989·Journal of Bioenergetics and Biomembranes·A PietrangeloA Masini
Nov 1, 1991·Biulleten' eksperimental'noĭ biologii i meditsiny·Iu V GladyshevA V Sviridov
Jan 1, 1991·Archives of Toxicology·D MüllerR Dargel
Jan 1, 1992·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·T Morimoto, W Isselhard
Jan 1, 1996·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·T ImaiM Makuuchi
Mar 1, 1991·Biochemical Pharmacology·D D Jamieson
Feb 4, 1992·Biochemical Pharmacology·M HicksR O Day
Jan 1, 1994·Molecular Aspects of Medicine·G Desoye, E Shafrir
Nov 1, 1993·General Pharmacology·B KaplanN Turkozkan
May 1, 1995·Free Radical Biology & Medicine·F BiasiG Poli
Sep 1, 1994·Free Radical Biology & Medicine·F BiasiG Poli
Sep 1, 1995·Free Radical Biology & Medicine·F BiasiE Andorno
Feb 14, 2006·Chemico-biological Interactions·Hiroyuki YokoyamaShoji Awazu
Jul 14, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C LoguercioUNKNOWN Italian AISF Clinical Group
Jul 15, 2004·Toxicology in Vitro : an International Journal Published in Association with BIBRA·She-Ching Wu, Gow-Chin Yen
Jan 15, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·P Abraham Cathrine
Aug 2, 2003·Molecular Aspects of Medicine·Werner Siems, Tilman Grune
Dec 1, 1997·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H JinnoM Ando
Jan 1, 1997·Free Radical Biology & Medicine·G Poli, M Parola
Feb 7, 2012·Expert Reviews in Molecular Medicine·Xinsheng Gu, Jose E Manautou
Sep 10, 2011·Antioxidants & Redox Signaling·Rakesh Kumar Tandon, Pramod Kumar Garg
May 12, 2012·Thyroid : Official Journal of the American Thyroid Association·Till IttermannHenry Völzke

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