The role of lipids in the pathogenesis of glomerulosclerosis in the rat following subtotal nephrectomy

European Journal of Clinical Investigation
H C RaynerJ Walls

Abstract

Similarities between atherosclerosis and glomerulosclerosis suggest that hyperlipidaemia may contribute to glomerular injury. Dietary supplementation with 4% cholesterol + 1% cholic acid was administered to rats 4 weeks after 1 1/3 nephrectomy and continued for 7 weeks. There was a significant increase in serum cholesterol (peak = 11.52 +/- 1.09 mmol l-1 vs. 4.73 +/- 0.31 on control diet, P less than 0.001) and triglyceride concentrations (peak = 2.31 +/- 0.27 mmol l-1 vs. 1.41 +/- 0.29, P less than 0.05) and a marked increase in beta-migrating lipoproteins. The severity of hypercholesterolaemia was significantly correlated with proteinuria (control diet: r = 0.600, cholesterol diet: r = 0.672, P less than 0.0001) as was hypertriglyceridaemia (control diet: r = 0.544, cholesterol diet: r = 0.678, P less than 0.0001). The percentage of glomeruli containing lipid deposits was increased from 21% to 60% (P less than 0.05). The kidney total cholesterol content was increased from 29.2 +/- 0.8 to 47.7 +/- 3.3 mumols g-1 dry weight (P less than 0.0001), with esterified cholesterol increasing from 7.5 +/- 0.4% to 14.5 +/- 2.1% of total (P less than 0.01). Serum cholesterol concentration was significantly correlated with both glomerular ...Continue Reading

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Citations

May 31, 2012·Current Diabetes Reports·Anil Karihaloo
Jun 16, 2000·Journal of Atherosclerosis and Thrombosis·T NagaiM Mori
Mar 12, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Ali OlyaeiJose Rueda
May 5, 2010·Nature Reviews. Nephrology·Anne-Emilie Declèves, Kumar Sharma
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Apr 9, 2009·Pharmacology & Therapeutics·Theodoros I Kassimatis, Panagiotis A Konstantinopoulos

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