The role of liver alcohol dehydrogenase isoenzymes in the oxidation of glycolethers in male and female rats

Toxicology and Applied Pharmacology
L AasmoeJ Aarbakke

Abstract

The glycolethers 2-methoxyethanol (2-ME), 2-ethoxyethanol (2-EE), and 2-butoxyethanol (2-BE) are used as solvents and have teratogenic, spermatotoxic, and hematotoxic effects. These glycolethers are oxidized to their corresponding alkoxyacetic acids, probably by alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). This metabolic conversion of the glycolethers is a prerequisite for development of toxicity, as the toxic effects have been shown to be due to the alkoxyacetic acid metabolites. Three isoenzymes of ADH have been detected in rat tissues. The liver contains two of these isoenzymes, ADH-2 and ADH-3. It has also been shown that the activity level of ADH is strongly sex dependent, with higher activity in females than in males. In the present study, we have investigated whether one or both of the ADH isoenzymes in male and female rat livers were able to oxidize 2-ME, 2-EE, and 2-BE and whether one or both of the ADH isoenzymes in male rat liver were able to oxidize 2-pentyloxyethanol and 2-hexyloxyethanol. Our results indicated that only the ADH-3 isoenzyme effectively oxidized the glycolethers in rat liver. Both ADH-2 and ADH-3 were able to oxidize medium chain aliphatic alcohols with a chain length corresponding...Continue Reading

References

Jul 1, 1992·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·P J SabourinR F Henderson
Mar 1, 1990·Toxicology and Applied Pharmacology·M A MedinskyR F Henderson
Jul 1, 1985·Toxicology and Applied Pharmacology·E J MossT J Gray
Jul 1, 1985·Toxicology and Applied Pharmacology·T J GrayS D Gangolli
Oct 1, 1985·Toxicology and Applied Pharmacology·J C LambP S Sabharwal
Jan 1, 1985·Drug and Chemical Toxicology·K G RömerK J Freundt
Aug 1, 1984·Environmental Health Perspectives·K L CheeverW W Weigel
Aug 1, 1984·Environmental Health Perspectives·P M FosterT J Gray
Aug 1, 1984·Environmental Health Perspectives·B K NelsonP T Goad
Jul 1, 1982·Journal of Endocrinological Investigation·R Teschke, B Wiese
Jul 1, 1983·Toxicology and Applied Pharmacology·P M FosterS D Gangolli
Jan 1, 1982·Drug and Chemical Toxicology·B D HardinT F Weaver
Jul 1, 1982·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R R MillerM J McKenna
Jan 1, 1981·Toxicology·K NaganoK Yamazaki

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Citations

May 9, 2007·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M Miura, T Ohkubo
Oct 27, 2010·Toxicology Letters·Zhao-Ying LiuZong-Hui Yuan
Oct 18, 2015·International Journal of Hygiene and Environmental Health·Torka PoetSean M Hays
Nov 5, 2005·Alcoholism, Clinical and Experimental Research·Ken D SumidaAleksey V Matveyenko
Aug 4, 2001·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·B I GhanayemA Nyska
Aug 22, 2008·International Journal of Occupational Medicine and Environmental Health·Andrzej StarekWiesław Szymczak
Feb 26, 2015·Pharmacological Reports : PR·Beata Starek-ŚwiechowiczAndrzej Starek
Oct 1, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·X ZhangX Qu
Jan 1, 2005·Toxicology Mechanisms and Methods·Clayton B'hymerKenneth L Cheever
Jul 13, 2000·Human & Experimental Toxicology·B I GhanayemA Nyska
Oct 19, 1999·Human & Experimental Toxicology·A NyskaB I Ghanayem
Jun 29, 2005·International Journal of Toxicology·UNKNOWN Cosmetic Ingredient Review Expert Panel
Nov 21, 2017·Annals of Occupational and Environmental Medicine·Seng-Ho SongSang-Ha Lee
Sep 30, 2004·Archives of Toxicology·David J LockleyFaith M Williams
Jun 13, 2012·The Journal of Toxicological Sciences·Takashi YamadaMakoto Hayashi
Jun 17, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Lifei WangDonglu Zhang
Nov 22, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Xingxing DiaoXiaoyan Chen
Aug 3, 2010·Pharmaceutical Biology·Jian DuKhalid Rahman
May 15, 2012·Pharmacological Reports : PR·Beata Starek-ŚwiechowiczAndrzej Starek
Nov 20, 2004·Archives of Toxicology·David J LockleyFaith M Williams
May 2, 2020·Biodegradation·Christine WoiskiKarl-Heinrich Engesser
Nov 2, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiS Tsang
May 5, 2000·Biochemical Pharmacology·L Aasmoe, J Aarbakke
Apr 24, 2002·Toxicology and Applied Pharmacology·David J LockleyFaith M Williams
Oct 26, 2002·Chemico-biological Interactions·John S WalshLinda M Thurmond

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